Phenotypic Discovery of an Antivirulence Agent against Vibrio vulnificus via Modulation of Quorum-Sensing Regulator SmcR.
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DOI: 10.1021/acsinfecdis.0c00587
Abstract: An antivirulence agent against Vibrio vulnificus named quoromycin (QM) was discovered by a phenotype-based elastase inhibitor screening. Using the fluorescence difference in two-dimensional gel electrophoresis (FITGE) approach, SmcR, a quorum-sensing master regulator and homologue of… read more here.
Keywords: quorum sensing; smcr; antivirulence agent; vulnificus ... See more keywords
Exploring the repurposed role of solithromycin as an antivirulence agent against Staphylococcus aureus and its resistant variants
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DOI: 10.3389/fmicb.2025.1540997
Abstract: Introduction Staphylococcus aureus is a bacterium that can cause various infections. The rise in Staphylococcal-resistant infections has led to the need for new treatments. The accessory gene regulator (agr) quorum-sensing system, which regulates the expression… read more here.
Keywords: antivirulence; aureus; sol; mrsa agra ... See more keywords
Antivirulence Agent as an Adjuvant of β-Lactam Antibiotics in Treating Staphylococcal Infections
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DOI: 10.3390/antibiotics11060819
Abstract: Staphylococcus aureus can cause a plethora of life-threatening infections. Antibiotics have been extensively used to treat S. aureus infections. However, when antibiotics are used at sub-inhibitory concentrations, especially for β-lactam antibiotics, they may enhance staphylococcal… read more here.
Keywords: antivirulence; agent adjuvant; antivirulence agent; m21 ... See more keywords