Cross-reactivity between annexin A2 and Beta-2-glycoprotein I in animal models of antiphospholipid syndrome
Sign Up to like & getrecommendations! Published in 2017 at "Immunologic Research"
DOI: 10.1007/s12026-016-8840-8
Abstract: Antiphospholipid syndrome (APS) affects coagulation and the brain by autoimmune mechanisms. The major antigen in APS is beta-2-glycoprotein I (β2-GPI) is known to complex with annexin A2 (ANXA2), and antibodies to ANXA2 have been described… read more here.
Keywords: antiphospholipid syndrome; anxa2 antibodies; annexin; beta glycoprotein ... See more keywords
Preeclampsia: a defect in decidualization is associated with deficiency of Annexin A2.
Sign Up to like & getrecommendations! Published in 2019 at "American journal of obstetrics and gynecology"
DOI: 10.1016/j.ajog.2019.11.1250
Abstract: BACKGROUND Decidualization defects in the endometrium have been demonstrated at the time of delivery in women with severe preeclampsia (sPE) and linger for years, suggesting a maternal contribution to the pathogenesis of this condition. Global… read more here.
Keywords: spe; annexin; anxa2; preeclampsia ... See more keywords
Identification of ANXA2 (annexin A2) as a specific bleomycin target to induce pulmonary fibrosis by impeding TFEB-mediated autophagic flux
Sign Up to like & getrecommendations! Published in 2018 at "Autophagy"
DOI: 10.1080/15548627.2017.1409405
Abstract: ABSTRACT Bleomycin is a clinically potent anticancer drug used for the treatment of germ-cell tumors, lymphomas and squamous-cell carcinomas. Unfortunately, the therapeutic efficacy of bleomycin is severely hampered by the development of pulmonary fibrosis. However,… read more here.
Keywords: fibrosis; bleomycin; target; autophagic flux ... See more keywords
EpithelialâMesenchymal Transition in colorectal cancer: Annexin A2 is caught in the crosshairs
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16962
Abstract: To the Editor, Epithelialmesenchymal transition (EMT) is a complex cellular program where cells transit between epithelial and mesenchymal phenotypes. It is mainly characterized by the loss of apicalbasal polarity, disassembly or reorganization of cellcell junctions… read more here.
Keywords: emt; transition; colorectal cancer; epithelial mesenchymal ... See more keywords
Abstract 1314: Molecular contribution of Annexin A2 in triple negative breast cancer metastasis via tumor-derived extracellular vesicles
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1314
Abstract: Triple negative breast cancer (TNBC) is the most lethal subtype of all breast cancers leading to high mortality rates. Tumor-derived extracellular vesicles (TEV) along with their cell-type specific cargo are greatly implicated in tissue-specific metastasis.… read more here.
Keywords: metastasis; extracellular vesicles; breast; derived extracellular ... See more keywords
An Integrative Data Mining and Omics-Based Translational Model for the Identification and Validation of Oncogenic Biomarkers of Pancreatic Cancer
Sign Up to like & getrecommendations! Published in 2019 at "Cancers"
DOI: 10.3390/cancers11020155
Abstract: Substantial alterations at the multi-omics level of pancreatic cancer (PC) impede the possibility to diagnose and treat patients in early stages. Herein, we conducted an integrative omics-based translational analysis, utilizing next-generation sequencing, transcriptome meta-analysis, and… read more here.
Keywords: omics based; validation; based translational; pancreatic cancer ... See more keywords