The anxiolytic-like effects of puerarin are associated with the changes of monoaminergic neurotransmitters and biosynthesis of allopregnanolone in the brain
Sign Up to like & getrecommendations! Published in 2017 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-017-0127-9
Abstract: Anxiety disorder is a serious and burdensome psychiatric illness that frequently turn into chronic clinical conditions. Puerarin have been shown to be effective in the therapy of depression. However, few studies are concerned about the… read more here.
Keywords: biosynthesis allopregnanolone; effects puerarin; anxiolytic like; like effects ... See more keywords
Taurine enhances voluntary alcohol intake and promotes anxiolytic-like behaviors in rats.
Sign Up to like & getrecommendations! Published in 2020 at "Alcohol"
DOI: 10.1016/j.alcohol.2020.07.004
Abstract: Taurine is an amino acid usually added to energy drinks. In rodents, acute taurine administration decreases voluntary alcohol intake and sub chronic administration restores different behavioral features impaired by alcohol withdrawal. In the present study,… read more here.
Keywords: alcohol intake; voluntary alcohol; taurine enhances; alcohol ... See more keywords
Neuropharmacological assessment in mice and molecular docking of piperazine derivative LQFM212
Sign Up to like & getrecommendations! Published in 2020 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2020.112827
Abstract: Piperazine derivatives are an attractive class of chemical compounds for the treatment of various mental illness. Herein, we demonstrated the synthesis of LQFM212, a piperazine derivative, behavioral evaluation in mice and computational studies. In neuropharmacological… read more here.
Keywords: piperazine derivative; neuropharmacological assessment; lqfm212; anxiolytic like ... See more keywords
Identification of Rubisco anxiolytic-like peptides (rALPs) by comprehensive analysis of spinach green leaf protein digest.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.09.195
Abstract: Rubisco, an enzyme for photosynthetic carbon dioxide fixation, is a major green leaf protein and known as the most abundant protein on the Earth. We found that Rubisco digested mimicking gastrointestinal enzymatic conditions exhibited anxiolytic-like… read more here.
Keywords: protein; ralp ralp; ralp; green leaf ... See more keywords
Repeated arctigenin treatment produces antidepressant- and anxiolytic-like effects in mice
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2018.12.005
Abstract: Depression is the root of various diseases. It is one of the most debilitating conditions globally. Antidepressant drugs are usually the first-line of depression treatment. Arctigenin (ARC), one of active ingredient of Arctium lappa L,… read more here.
Keywords: arc administration; antidepressant anxiolytic; treatment; like effects ... See more keywords
Characterization of 6‐methoxyflavanone as a novel anxiolytic agent: A behavioral and pharmacokinetic approach
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2017.02.047
Abstract: ABSTRACT Benzodiazepines are regularly prescribed for treatment of anxiety though there are side effects. Flavonoids have selective affinity for GABAA receptors implicated in anxiolytic‐like activity in rodents, but are devoid of the unwanted side effects… read more here.
Keywords: meof; methoxyflavanone novel; characterization methoxyflavanone; open field ... See more keywords
4-phenylselenyl-7-chloroquinoline, a novel multitarget compound with anxiolytic activity: Contribution of the glutamatergic system.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of psychiatric research"
DOI: 10.1016/j.jpsychires.2016.10.007
Abstract: A growing body of evidence demonstrates that quinoline compounds have attracted much attention in the field of drug development. Accordingly, 4-phenylselenyl-7-chloroquinoline (4-PSQ) is a new quinoline derivative containing selenium, which showed a potential antioxidant, antinociceptive… read more here.
Keywords: glutamatergic system; psq; anxiolytic like; activity ... See more keywords
Activation and blockade of basolateral amygdala 5-HT6 receptor produce anxiolytic-like behaviors in an experimental model of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2018 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.05.016
Abstract: &NA; Although the basolateral amygdala (BLA) and serotonin6 (5‐HT6) receptor are involved in modulation of anxiety, their roles in Parkinson' disease (PD)‐related anxiety are still unknown. Thus we perform this study to examine the involvement… read more here.
Keywords: receptor; bla ht6; anxiolytic like; ht6 receptor ... See more keywords
Cannabinoid CB2 receptors mediate the anxiolytic-like effects of monoacylglycerol lipase inhibition in a rat model of predator-induced fear
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DOI: 10.1038/s41386-020-0696-x
Abstract: The endocannabinoid system is a key regulator of the response to psychological stress. Inhibitors of monoacylglycerol lipase (MGL), the enzyme that deactivates the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG), exert anxiolytic-like effects in rodent models via 2-AG-dependent activation… read more here.
Keywords: cb2 receptors; induced fear; like effects; cb2 ... See more keywords
The anxiolytic-like effect of rutin in rats involves GABAA receptors in the basolateral amygdala
Sign Up to like & getrecommendations! Published in 2017 at "Behavioural Pharmacology"
DOI: 10.1097/fbp.0000000000000290
Abstract: Rutin is a bioflavonoid found in medicinal plants used to reduce anxiety. Evidence is lacking of rutin’s anxiolytic-like activity, putative mechanism(s) of action, and neural sites of effects. The basolateral amygdala (BLA) is the main… read more here.
Keywords: effect rutin; like effect; basolateral amygdala; rutin ... See more keywords
First evaluation of the anxiolytic-like effects of a bromazepam‑palladium complex in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of inorganic biochemistry"
DOI: 10.2139/ssrn.4119250
Abstract: A significant fraction of patients are affected by persistent fear and anxiety. Currently, there are several anxiolytic drug options, however their clinical outcomes do not fully manage the symptoms. Here, we evaluated the effects of… read more here.
Keywords: effects bromazepam; anxiolytic like; bmz pdcl2; bromazepam palladium ... See more keywords