TRIM36 Inhibits the Development of AOM/DSS‐Induced Colitis‐Associated Colorectal Cancer by Promoting the Ubiquitination and Degradation of GRB7
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23871
Abstract: Colorectal cancer (CRC) is among the most common cancer types for both sexes. Tripartite motif 36 (TRIM36) has been reported to be aberrantly expressed in several cancer types, suggesting its involvement in cancer progression. However,… read more here.
Keywords: cancer; trim36; dss induced; crc ... See more keywords
Bifidobacterium lactis ameliorates AOM/DSS-induced inflammation, dysbiosis, and colonic precancerous lesions
Sign Up to like & getrecommendations! Published in 2025 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-025-13445-x
Abstract: Bowel cancer is the third most common malignancy of tumors and one of the major causes of cancer-related death. Bowel precancerous conditions can develop without any symptoms, which either makes it difficult for early diagnosis… read more here.
Keywords: colonic precancerous; dss induced; precancerous lesions; lactis ... See more keywords
Protective effect of Pai-Nong-San against AOM/DSS-induced CAC in mice through inhibiting the Wnt signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Chinese journal of natural medicines"
DOI: 10.1016/s1875-5364(22)60143-2
Abstract: Pai-Nong-San (PNS), a prescription of traditional Chinese medicine, has been used for years to treat abscessation-induced diseases including colitis and colorectal cancer. This study was aimed to investigate the preventive effects and possible protective mechanism… read more here.
Keywords: dss induced; dss; signaling pathway; wnt signaling ... See more keywords
Chemotherapy-induced mucositis development in a murine model of colitis-associated colorectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "Scandinavian Journal of Gastroenterology"
DOI: 10.1080/00365521.2019.1699601
Abstract: Abstract Objectives: Ulcerative colitis is an incurable inflammatory bowel disease that increases the risk of colorectal cancer (CRC). 5-Fluorouracil (5-FU) is the predominant chemotherapy for CRC patients; however, undesirable side-effects, including mucositis, are common. This… read more here.
Keywords: mucositis; model colitis; colorectal cancer; colitis ... See more keywords
Tanshinone IIA attenuates AOM/DSS-induced colorectal tumorigenesis in mice via inhibition of intestinal inflammation.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutical biology"
DOI: 10.1080/13880209.2020.1865412
Abstract: CONTEXT Tanshinone IIA is a natural extract derived from a Chinese medicinal herb with multiple bioactivities; however, whether and how tanshinone IIA protects against colorectal cancer (CRC) are uncertain. OBJECTIVE We investigated the potential beneficial… read more here.
Keywords: tanshinone; mice; tanshinone iia; aom dss ... See more keywords
Emu Oil And Grape Seed Extract Reduce Tumour Burden And Disease Parameters In Murine Colitis-Associated Colorectal Cancer.
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DOI: 10.1093/carcin/bgaa099
Abstract: Ulcerative colitis (UC) is an incurable condition whereby patients are at an increased risk of developing colorectal cancer (CRC). We aimed to investigate the combination of Emu Oil and grape seed extract (GSE) in an… read more here.
Keywords: seed; gse; colitis; mice ... See more keywords
Glutathione Transferase Omega 1 confers protection against azoxymethane-induced colorectal tumour formation.
Sign Up to like & getrecommendations! Published in 2021 at "Carcinogenesis"
DOI: 10.1093/carcin/bgab008
Abstract: Inflammatory bowel disease (IBD) is characterized by multiple alterations in cytokine expression and is a risk factor for colon cancer. The Omega class glutathione transferase GSTO1-1 regulates the release of the pro-inflammatory cytokines interleukin 1β… read more here.
Keywords: glutathione transferase; colon; mice; aom dss ... See more keywords
The chemopreventive effect of withaferin A on spontaneous and inflammation-associated colon carcinogenesis models
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DOI: 10.1093/carcin/bgy109
Abstract: Chemopreventive effects and associated mechanisms of withaferin A (WA) against intestinal and colon carcinogenesis remain unknown. We investigated the chemopreventive effect of WA on transgenic adenomatous polyposis coli (APCMin/+) mouse and chemically induced azoxymethane/dextran sodium… read more here.
Keywords: colon carcinogenesis; colon; chemopreventive effect; aom dss ... See more keywords
Therapeutic potential of Pien Tze Huang in colitis-associated colorectal cancer: mechanistic insights from a mouse model
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DOI: 10.1186/s12935-024-03428-9
Abstract: Pien Tze Huang (PZH), a traditional Chinese medicine formulation, is recognized for its therapeutic effect on colitis and colorectal cancer. However, its protective role and underlying mechanism in colitis-associated colorectal cancer (CAC) remain to be… read more here.
Keywords: colorectal cancer; dss; colon; colitis ... See more keywords
Ginsenoside Rb1 Suppresses AOM/DSS-Induced Colon Carcinogenesis.
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DOI: 10.2174/1871520623666230119092735
Abstract: BACKGROUND Colorectal cancer (CRC) is the third most common cancer world-wide. Current treatments, including surgery, radiotherapy, and chemotherapy, are limited by severe side effects and the development of resistance. OBJECTIVE Therefore, it is important to… read more here.
Keywords: aom dss; ginsenoside rb1; cancer;
A Novel Modification of the AOM/DSS Model for Inducing Intestinal Adenomas in Mice
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DOI: 10.21873/anticanres.12616
Abstract: Background/Aim: Our aim was to develop an animal model of the precancerous stages of colitis-associated carcinogenesis by modifying the established azoxymethane/dextran sulfate sodium (AOM/DSS) protocol. Materials and Methods: Six mice were treated with varying cycles… read more here.
Keywords: aom dss; group; aom; mice ... See more keywords