Protective effect of Pai-Nong-San against AOM/DSS-induced CAC in mice through inhibiting the Wnt signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Chinese journal of natural medicines"
DOI: 10.1016/s1875-5364(22)60143-2
Abstract: Pai-Nong-San (PNS), a prescription of traditional Chinese medicine, has been used for years to treat abscessation-induced diseases including colitis and colorectal cancer. This study was aimed to investigate the preventive effects and possible protective mechanism… read more here.
Keywords: dss induced; dss; signaling pathway; wnt signaling ... See more keywords
Chemotherapy-induced mucositis development in a murine model of colitis-associated colorectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "Scandinavian Journal of Gastroenterology"
DOI: 10.1080/00365521.2019.1699601
Abstract: Abstract Objectives: Ulcerative colitis is an incurable inflammatory bowel disease that increases the risk of colorectal cancer (CRC). 5-Fluorouracil (5-FU) is the predominant chemotherapy for CRC patients; however, undesirable side-effects, including mucositis, are common. This… read more here.
Keywords: mucositis; model colitis; colorectal cancer; colitis ... See more keywords
Tanshinone IIA attenuates AOM/DSS-induced colorectal tumorigenesis in mice via inhibition of intestinal inflammation.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutical biology"
DOI: 10.1080/13880209.2020.1865412
Abstract: CONTEXT Tanshinone IIA is a natural extract derived from a Chinese medicinal herb with multiple bioactivities; however, whether and how tanshinone IIA protects against colorectal cancer (CRC) are uncertain. OBJECTIVE We investigated the potential beneficial… read more here.
Keywords: tanshinone; mice; tanshinone iia; aom dss ... See more keywords
Emu Oil And Grape Seed Extract Reduce Tumour Burden And Disease Parameters In Murine Colitis-Associated Colorectal Cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Carcinogenesis"
DOI: 10.1093/carcin/bgaa099
Abstract: Ulcerative colitis (UC) is an incurable condition whereby patients are at an increased risk of developing colorectal cancer (CRC). We aimed to investigate the combination of Emu Oil and grape seed extract (GSE) in an… read more here.
Keywords: seed; gse; colitis; mice ... See more keywords
Glutathione Transferase Omega 1 confers protection against azoxymethane-induced colorectal tumour formation.
Sign Up to like & getrecommendations! Published in 2021 at "Carcinogenesis"
DOI: 10.1093/carcin/bgab008
Abstract: Inflammatory bowel disease (IBD) is characterized by multiple alterations in cytokine expression and is a risk factor for colon cancer. The Omega class glutathione transferase GSTO1-1 regulates the release of the pro-inflammatory cytokines interleukin 1β… read more here.
Keywords: glutathione transferase; colon; mice; aom dss ... See more keywords
The chemopreventive effect of withaferin A on spontaneous and inflammation-associated colon carcinogenesis models
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DOI: 10.1093/carcin/bgy109
Abstract: Chemopreventive effects and associated mechanisms of withaferin A (WA) against intestinal and colon carcinogenesis remain unknown. We investigated the chemopreventive effect of WA on transgenic adenomatous polyposis coli (APCMin/+) mouse and chemically induced azoxymethane/dextran sodium… read more here.
Keywords: colon carcinogenesis; colon; chemopreventive effect; aom dss ... See more keywords
Ginsenoside Rb1 Suppresses AOM/DSS-Induced Colon Carcinogenesis.
Sign Up to like & getrecommendations! Published in 2023 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520623666230119092735
Abstract: BACKGROUND Colorectal cancer (CRC) is the third most common cancer world-wide. Current treatments, including surgery, radiotherapy, and chemotherapy, are limited by severe side effects and the development of resistance. OBJECTIVE Therefore, it is important to… read more here.
Keywords: aom dss; ginsenoside rb1; cancer;
A Novel Modification of the AOM/DSS Model for Inducing Intestinal Adenomas in Mice
Sign Up to like & getrecommendations! Published in 2018 at "AntiCancer Research"
DOI: 10.21873/anticanres.12616
Abstract: Background/Aim: Our aim was to develop an animal model of the precancerous stages of colitis-associated carcinogenesis by modifying the established azoxymethane/dextran sulfate sodium (AOM/DSS) protocol. Materials and Methods: Six mice were treated with varying cycles… read more here.
Keywords: aom dss; group; aom; mice ... See more keywords
Maggot extracts chemo-prevent inflammation and tumorigenesis accompanied by changes in the intestinal microbiome and metabolome in AOM/DSS-induced mice
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2023.1143463
Abstract: Inflammatory responses and intestinal microbiome play a crucial role in the progression of colitis-associated carcinoma (CAC). The traditional Chinese medicine maggot has been widely known owing to its clinical application and anti-inflammatory function. In this… read more here.
Keywords: administration; dss; dss induced; aom dss ... See more keywords
Emodin Inhibits Inflammation, Carcinogenesis, and Cancer Progression in the AOM/DSS Model of Colitis-Associated Intestinal Tumorigenesis
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.564674
Abstract: Colorectal cancer (CRC) is one of the most common cancer worldwide. Chronic inflammation contributes to CRC development and progression. Emodin, is a natural anthraquinone derivative with anti-oxidant, anti-inflammatory, and anti-tumor activities. We used the AOM/DSS… read more here.
Keywords: inflammation; associated intestinal; aom dss; cancer ... See more keywords
Albuca Bracteata Polysaccharides Attenuate AOM/DSS Induced Colon Tumorigenesis via Regulating Oxidative Stress, Inflammation and Gut Microbiota in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.833077
Abstract: Inflammation is an important risk factor in the development of inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC). Accumulating evidence indicates that some phytochemicals have anti-cancer properties. Polysaccharides extracted from Albuca bracteata (AB) have… read more here.
Keywords: inflammation; dss induced; oxidative stress; mice ... See more keywords