Attenuation of Maladaptive Responses in Aortic Adventitial Fibroblasts through Stimuli‐Triggered siRNA Release from Lipid–Polymer Nanocomplexes
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DOI: 10.1002/adbi.201700099
Abstract: Lipid–siRNA assemblies are modified with photoresponsive polymers to enable spatiotemporally controlled silencing of interleukin 1 beta (IL1β) and cadherin 11 (CDH11), two genes that are essential drivers of maladaptive responses in human aortic adventitial fibroblasts.… read more here.
Keywords: adventitial fibroblasts; lipid polymer; attenuation maladaptive; aortic adventitial ... See more keywords
Aortic adventitial thickness as a marker of aortic atherosclerosis, vascular stiffness, and vessel remodeling in systemic lupus erythematosus
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DOI: 10.1007/s10067-020-05431-7
Abstract: There is limited human imaging data on the association of adventitial thickness (AT) with arterial disease. Systemic lupus erythematosus (SLE) is a prototypical disease model for studying markers of premature arterial disease. To determine if… read more here.
Keywords: aortic atherosclerosis; stiffness; vessel remodeling; aortic adventitial ... See more keywords
T-614 inhibits human aortic adventitial fibroblast proliferation and promotes interleukin-8 production in vitro
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DOI: 10.1177/1708538119880088
Abstract: Objectives The effect and underlying mechanism of T-614 (iguratimod) on Takayasu’s arteritis (TA) are unknown. Here, we report the effects of T-614 on cell proliferation and interleukin-8 (IL-8) production in human aortic adventitial fibroblasts (HAAFs)… read more here.
Keywords: production; presence; proliferation; aortic adventitial ... See more keywords