Tongsaimai reverses the hypertension and left ventricular remolding caused by abdominal aortic constriction in rats.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2019.112154
Abstract: Treating ventricular remodeling continues to be a clinical challenge. Studies have shown that hypertension is one of the most common causes of ventricular remodeling, and is a major cause of cardiovascular risk in adults. Here,… read more here.
Keywords: hypertension left; abdominal aortic; aortic constriction; left ventricular ... See more keywords
Early echocardiographic predictors of outcomes in the mouse transverse aortic constriction heart failure model.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmacological and toxicological methods"
DOI: 10.1016/j.vascn.2016.12.001
Abstract: INTRODUCTION Mouse transverse aortic constriction (TAC) is a widely-used model of pressure overload-induced heart failure. An intrinsic limitation of the model is variability in the response to pressure overload even when employing a standard severity… read more here.
Keywords: end study; heart; aortic constriction; mouse transverse ... See more keywords
A surgical mouse model of neonatal pressure overload by transverse aortic constriction.
Sign Up to like & getrecommendations! Published in 2020 at "Nature protocols"
DOI: 10.1038/s41596-020-00434-9
Abstract: Cardiac disease is the main cause of death worldwide. Insufficient regeneration of the adult mammalian heart is a major driver of cardiac morbidity and mortality. Cardiac regeneration occurs in early postnatal mice, thus understanding mechanisms… read more here.
Keywords: pressure overload; aortic constriction; model; transverse aortic ... See more keywords
Distinct Phenotypes Induced by Three Degrees of Transverse Aortic Constriction in Mice
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-42209-7
Abstract: Transverse aortic constriction (TAC) is a well-established model of pressure overload-induced cardiac hypertrophy and failure in mice. The degree of constriction “tightness” dictates the TAC severity and is determined by the gauge (G) of needle… read more here.
Keywords: distinct phenotypes; aortic constriction; tac; mice ... See more keywords
Paeonol attenuates heart failure induced by transverse aortic constriction via ERK1/2 signalling
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2022.2040543
Abstract: Abstract Context Paeonol (PAE) is the main phytochemical from Cortex Moutan. Its main pharmacological effects are anti-inflammatory and antioxidant, but its cardioprotective effect is unclear. Objective The study investigates the effects and underlying mechanisms of… read more here.
Keywords: transverse aortic; paeonol; showed pae; tac ... See more keywords
Noncanonical Form of ERAD Regulates Cardiac Hypertrophy
Sign Up to like & getrecommendations! Published in 2022 at "Circulation"
DOI: 10.1161/circulationaha.122.061557
Abstract: Background: Cardiac hypertrophy increases demands on protein folding, which causes an accumulation of misfolded proteins in the endoplasmic reticulum (ER). These misfolded proteins can be removed by the adaptive retrotranslocation, polyubiquitylation, and a proteasome-mediated degradation… read more here.
Keywords: transverse aortic; cardiac hypertrophy; erad; heart ... See more keywords
Impact of delayed type hypersensitivity arthritis on development of heart failure by aortic constriction in mice
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0262821
Abstract: Aims Patients with rheumatoid arthritis (RA) have increased risk of heart failure (HF). The mechanisms and cardiac prerequisites explaining this association remain unresolved. In this study, we sought to determine the potential cardiac impact of… read more here.
Keywords: heart failure; hypersensitivity arthritis; type hypersensitivity; aortic constriction ... See more keywords
Dihydromyricetin Attenuates Myocardial Hypertrophy Induced by Transverse Aortic Constriction via Oxidative Stress Inhibition and SIRT3 Pathway Enhancement
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19092592
Abstract: Dihydromyricetin (DMY), one of the flavonoids in vine tea, exerts several pharmacological actions. However, it is not clear whether DMY has a protective effect on pressure overload-induced myocardial hypertrophy. In the present study, male C57BL/6… read more here.
Keywords: oxidative stress; transverse aortic; aortic constriction; myocardial hypertrophy ... See more keywords