Suppression of Lysophosphatidylcholine-Induced Human Aortic Smooth Muscle Cell Calcification by Protein Kinase A Inhibition.
Sign Up to like & getrecommendations! Published in 2019 at "Lipids"
DOI: 10.1002/lipd.12178
Abstract: Lysophosphatidylcholine (lysoPtdCho) is produced mainly by the phospholipase A2-dependent hydrolysis of phosphatidylcholine (PtdCho) and can induce inflammatory activation and osteogenic gene expression in vascular smooth muscle cells. However, the mechanisms mediating these processes have not… read more here.
Keywords: calcification; aortic smooth; smooth muscle; protein kinase ... See more keywords
AFM Stiffness Mapping in Human Aortic Smooth Muscle Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biomechanical engineering"
DOI: 10.1115/1.4053657
Abstract: Aortic Smooth Muscle Cells (SMCs) play a vital role in maintaining mechanical homeostasis in the aorta. We recently found that SMCs of aneurysmal aortas apply larger traction forces than SMCs of healthy aortas. This result… read more here.
Keywords: aortic smooth; muscle cells; stiffness; smcs ... See more keywords
Characterization of Mitochondria from Primary Isolated Mouse Aortic Smooth Muscle Cells
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5734718
Abstract: Sexual dimorphism is demonstrated in cardiovascular disease (CVD). Vascular dysfunction is a critical player in CVD involving mitochondrial respiration in aortic smooth muscle cells. In this study, we characterized contractile and synthetic gene expression, and… read more here.
Keywords: aortic smooth; physiology; asmc; respiration ... See more keywords
Aortic Stress Activates an Adaptive Program in Thoracic Aortic Smooth Muscle Cells That Maintains Aortic Strength and Protects Against Aneurysm and Dissection in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.122.318135
Abstract: Background: When aortic cells are under stress, such as increased hemodynamic pressure, they adapt to the environment by modifying their functions, allowing the aorta to maintain its strength. To understand the regulation of this adaptive… read more here.
Keywords: stress; adaptive response; aortic smooth; thoracic ... See more keywords
EphrinB2 promotes the human aortic smooth muscle cell growth and migration via mediating F-actin remodeling.
Sign Up to like & getrecommendations! Published in 2021 at "Vascular"
DOI: 10.1177/17085381211052196
Abstract: OBJECTIVES To evaluate the potential effect of EphrinB2 in human thoracic aortic dissection (TAD) and to illustrate the mechanisms governing the role of EphrinB2 in the growth of human aortic smooth muscle cells (HASMC). METHODS… read more here.
Keywords: human aortic; ephrinb2; migration; cell ... See more keywords
Genetic approaches to identify pathological limitations in aortic smooth muscle contraction
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0193769
Abstract: Aortic smooth muscle contains limiting amounts of myosin light chain kinase (MLCK) for myosin regulatory light chain (RLC) phosphorylation and contraction that predisposes to thoracic aortic disease in humans containing heterozygous loss-of-function mutations in MYLK.… read more here.
Keywords: myosin; muscle; aortic smooth; contraction ... See more keywords