LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "apap" as a keyword



Photo by enginakyurt from unsplash

Synthetic Biomarker Design by Using Analyte‐Responsive Acetaminophen

Sign Up to like & get
recommendations! Published in 2017 at "ChemBioChem"

DOI: 10.1002/cbic.201700023

Abstract: The use of synthetic biomarkers is an emerging technique to improve disease diagnosis. Here, we report a novel design strategy that uses analyte‐responsive acetaminophen (APAP) to expand the catalogue of analytes available for synthetic biomarker… read more here.

Keywords: synthetic biomarker; analyte responsive; responsive acetaminophen; apap ... See more keywords
Photo by markusspiske from unsplash

Oridonin ameliorates acetaminophen‐induced acute liver injury through ATF4/PGC‐1α pathway

Sign Up to like & get
recommendations! Published in 2022 at "Drug Development Research"

DOI: 10.1002/ddr.22024

Abstract: Acetaminophen (APAP) overdose‐induced acute liver injury (ALI) causes hepatocyte cell death, oxidative stress, and inflammation. Oridonin (Ori), a covalent NLRP3‐inflammasome inhibitor, ameliorates APAP‐induced ALI through an unclear molecular mechanism. This study found that Ori decreased… read more here.

Keywords: apap; atf4 pgc; liver injury; acute liver ... See more keywords
Photo by abeosorio from unsplash

Elevated ghrelin alters the behavioral effects of perinatal acetaminophen exposure in rats.

Sign Up to like & get
recommendations! Published in 2022 at "Developmental psychobiology"

DOI: 10.1002/dev.22252

Abstract: A growing body of evidence links prenatal and early postnatal acetaminophen (APAP) exposure to atypical development of brain and behavior. In adult rodents, APAP is known to produce oxidative stress and lower anxiety-related behavior following… read more here.

Keywords: apap; effects perinatal; ghrelin; exposure rats ... See more keywords
Photo from wikipedia

Noninvasive Assessment of APAP (N‐acetyl‐p‐aminophenol)‐Induced Hepatotoxicity Using Multiple MRI Parameters in an Experimental Rat Model

Sign Up to like & get
recommendations! Published in 2022 at "Journal of Magnetic Resonance Imaging"

DOI: 10.1002/jmri.28203

Abstract: Early detection and accurate assessment of N‐acetyl‐p‐aminophenol (APAP)‐induced hepatotoxicity can prevent further aggravation of liver injury and reduce the incidence of liver failure. read more here.

Keywords: apap; assessment; acetyl aminophenol; induced hepatotoxicity ... See more keywords
Photo by icevooortex from unsplash

Human multidrug resistance protein 4 (MRP4) is a cellular efflux transporter for paracetamol glutathione and cysteine conjugates

Sign Up to like & get
recommendations! Published in 2020 at "Archives of Toxicology"

DOI: 10.1007/s00204-020-02793-4

Abstract: Paracetamol (acetaminophen, APAP) overdose is a leading cause of acute drug-induced liver failure. APAP hepatotoxicity is mediated by the reactive metabolite N-acetyl- p -benzoquinone imine (NAPQI). NAPQI is inactivated by conjugation with glutathione (GSH) to… read more here.

Keywords: apap cys; cellular efflux; apap; gsh ... See more keywords
Photo by kel_foto from unsplash

Maternal paracetamol intake and fetal ductus arteriosus constriction/closure: comprehensive signal evaluation using the Austin Bradford Hill criteria.

Sign Up to like & get
recommendations! Published in 2021 at "European journal of clinical pharmacology"

DOI: 10.1007/s00228-020-03039-z

Abstract: PURPOSE Acetaminophen (APAP) is available over-the-counter and widely regarded as safe for use in pregnancy. APAP has been used to close a persistently patent ductus arteriosus. Fetal constriction/closure of the ductus arteriosus (FCCDA), of public… read more here.

Keywords: constriction closure; pharmacology; apap; ductus arteriosus ... See more keywords
Photo by sharonmccutcheon from unsplash

Acetaminophen reduces the protein levels of high affinity amino acid permeases and causes tryptophan depletion

Sign Up to like & get
recommendations! Published in 2018 at "Amino Acids"

DOI: 10.1007/s00726-018-2613-8

Abstract: In yeast, toxicity of acetaminophen (APAP), a frequently used analgesic and antipyretic drug, depends on ubiquitin-controlled processes. Previously, we showed a remarkable overlap in toxicity profiles between APAP and tyrosine, and a similarity with drugs… read more here.

Keywords: amino; amino acid; acid permeases; apap ... See more keywords
Photo by finnnyc from unsplash

APAP therapy does not improve impaired sleep quality and sympatho-vagal balance: a randomized trial in patients with obstructive sleep apnea and systolic heart failure

Sign Up to like & get
recommendations! Published in 2019 at "Sleep and Breathing"

DOI: 10.1007/s11325-019-01868-6

Abstract: Purpose In heart failure with reduced ejection fraction (HFrEF), the effects of automatic positive airway pressure therapy (APAP) for obstructive sleep apnea (OSA) on sleep quality and sympatho-vagal balance (SVB) are unknown. Methods In this… read more here.

Keywords: sleep quality; therapy; apap; heart failure ... See more keywords
Photo from wikipedia

Polyphenols reported to shift APAP-induced changes in MAPK signaling and toxicity outcomes.

Sign Up to like & get
recommendations! Published in 2017 at "Chemico-biological interactions"

DOI: 10.1016/j.cbi.2017.09.007

Abstract: Due to its widespread availability, acetaminophen (APAP) is the leading cause for drug-induced liver injury in many countries including United States and United Kingdom. When used as recommended, APAP is relatively safe. However, in overdose… read more here.

Keywords: induced changes; toxicity; mapk signaling; apap ... See more keywords
Photo by armandoascorve from unsplash

Synthesis of single atom cobalt dispersed on 2D carbon nanoplate and degradation of acetaminophen by peroxymonosulfate activation

Sign Up to like & get
recommendations! Published in 2022 at "Chemical Engineering Journal"

DOI: 10.1016/j.cej.2021.132027

Abstract: Abstract Single Co atoms dispersed on 2D carbon nanoplate catalyst (SA-Co CNP) was synthesized successfully by a facile one-step method. Its morphology and structure were characterized by SEM, TEM, HAADF-STEM, XRD and XPS. Results showed… read more here.

Keywords: pms; apap; dispersed carbon; nanoplate ... See more keywords
Photo by noaa from unsplash

Prenatal exposure to acetaminophen and children's language development at 30 months

Sign Up to like & get
recommendations! Published in 2018 at "European Psychiatry"

DOI: 10.1016/j.eurpsy.2017.10.007

Abstract: Abstract Objective: To examine prenatal APAP exposure in relation to language development in offspring at 30 months of age. Method: A population-based pregnancy cohort study including 754 women who enrolled in the Swedish Environmental Longitudinal,… read more here.

Keywords: exposure; development months; language development; apap ... See more keywords