Human multidrug resistance protein 4 (MRP4) is a cellular efflux transporter for paracetamol glutathione and cysteine conjugates
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DOI: 10.1007/s00204-020-02793-4
Abstract: Paracetamol (acetaminophen, APAP) overdose is a leading cause of acute drug-induced liver failure. APAP hepatotoxicity is mediated by the reactive metabolite N-acetyl- p -benzoquinone imine (NAPQI). NAPQI is inactivated by conjugation with glutathione (GSH) to… read more here.
Keywords: apap cys; cellular efflux; apap; gsh ... See more keywords