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Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.05.062
Abstract: AIM Acetaminophen (APAP) overdose is the most frequent cause of drug-induced liver damage. Magnolia officinalis is a traditional hepatoprotective Chinese medicine and Honokiol (HO) is the major active constituent. The present study was to investigate…
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Keywords:
protein adducts;
induced hepatotoxicity;
generation;
apap ... See more keywords
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Published in 2019 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2018.11.005
Abstract: Formation of acetaminophen (APAP) protein adducts are a critical feature of APAP hepatotoxicity, and circulating protein adducts have recently been utilized in bioassays for identification of APAP overdose in humans. Despite their clinical significance, mechanisms…
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Keywords:
protein adducts;
apap overdose;
release;
apap protein ... See more keywords