The Women's Health Initiative; hormone replacement therapy; and Surveillance, Epidemiology, and End Results data
Sign Up to like & getrecommendations! Published in 2020 at "Cancer"
DOI: 10.1002/cncr.33261
Abstract: 810 Cancer March 1, 2021 individually. However, because the test did not reject this theory for Black women (P = .10), age groups were analyzed together. When the P value was 7.0 were deemed extremely… read more here.
Keywords: apc values; apc; decline; epidemiology ... See more keywords
The anaphase‐promoting complex: A key mitotic regulator associated with somatic mutations occurring in cancer
Sign Up to like & getrecommendations! Published in 2019 at "Genes"
DOI: 10.1002/gcc.22820
Abstract: The anaphase‐promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that helps control chromosome separation and exit from mitosis in many different kinds of organisms, including yeast, flies, worms, and humans. This review represents a new… read more here.
Keywords: anaphase promoting; complex key; apc subunits; apc ... See more keywords
Examining the mechanistic relationship of APC/CCDH1 and its interphase inhibitor EMI1
Sign Up to like & getrecommendations! Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4324
Abstract: Proper protein destruction by the ubiquitin (Ub)‐proteasome system is vital for a faithful cell cycle. Hence, the activity of Ub ligases is tightly controlled. The Anaphase‐Promoting Complex/Cyclosome (APC/C) is a 1.2 MDa Ub ligase responsible for… read more here.
Keywords: emi1; relationship apc; mechanistic relationship; apc dependent ... See more keywords
Neuroprotection and vasculoprotection using genetically targeted protease-ligands
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research"
DOI: 10.1016/j.brainres.2019.03.010
Abstract: Thrombin and activated protein C (APC) are known coagulation factors that exhibit profound effects in brain by acting on the protease activated receptor (PAR). The wild type (WT) proteases appear to impact cell survival powerfully,… read more here.
Keywords: vascular disruption; protease; vasculoprotection using; apc ... See more keywords
Fission Yeast Apc15 Stabilizes MCC-Cdc20-APC/C Complexes, Ensuring Efficient Cdc20 Ubiquitination and Checkpoint Arrest
Sign Up to like & getrecommendations! Published in 2017 at "Current Biology"
DOI: 10.1016/j.cub.2017.03.013
Abstract: Summary During mitosis, cells must segregate the replicated copies of their genome to their daughter cells with extremely high fidelity. Segregation errors lead to an abnormal chromosome number (aneuploidy), which typically results in disease or… read more here.
Keywords: mcc; apc; cdc20; yeast ... See more keywords
MiR-208a aggravates H2O2-induced cardiomyocyte injury by targeting APC.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172668
Abstract: Oxidative stress injury, inducing cardiomyocyte injury, is the major denominator of many cardiovascular diseases. In present study, we aimed to explore the molecular mechanism of microRNA-208a (miR-208a) in oxidative stress-induced cardiomyocyte injury. In this study,… read more here.
Keywords: mir 208a; apc; cardiomyocyte injury; h2o2 induced ... See more keywords
Adenoma detection rates in colonoscopies for positive fecal immunochemical tests versus direct screening colonoscopies.
Sign Up to like & getrecommendations! Published in 2019 at "Gastrointestinal endoscopy"
DOI: 10.1016/j.gie.2018.11.014
Abstract: BACKGROUND AND AIMS Recent guidelines propose higher adenoma detection rate (ADR) benchmarks for colonoscopies performed for positive results for fecal immunochemical tests (FIT), but this is based on low-quality evidence. We aimed to compare ADR,… read more here.
Keywords: direct screening; fecal immunochemical; apc; adr ... See more keywords
Hyperoside ameliorates diabetic nephropathy induced by STZ via targeting the miR-499-5p/APC axis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2021.02.005
Abstract: Diabetic nephropathy is a serious complication of diabetes. Hyperoside has been widely reported to ameliorate diabetes-associated disease. The current study is designed to explore the mechanism of hyperoside in diabetic nephropathy. In the present study,… read more here.
Keywords: hyperoside ameliorates; apc; ameliorates diabetic; diabetic nephropathy ... See more keywords
Identification of ICAT as an APC Inhibitor, Revealing Wnt-Dependent Inhibition of APC-Axin Interaction.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.07.040
Abstract: Adenomatous polyposis coli (APC) and Axin are core components of the β-catenin destruction complex. How APC's function is regulated and whether Wnt signaling influences the direct APC-Axin interaction to inhibit the β-catenin destruction complex is… read more here.
Keywords: apc axin; catenin; apc; interaction ... See more keywords
Continued dominance of carotid endarterectomy over stenting in the United States: Volumes, outcomes, and complications from the National Inpatient Sample (1997-2015).
Sign Up to like & getrecommendations! Published in 2022 at "World neurosurgery"
DOI: 10.1016/j.wneu.2022.03.110
Abstract: BACKGROUND The introduction of carotid stenting (CAS) has led to numerous comparative trials with carotid endarterectomy (CEA). OBJECTIVE To review real-world volumes, outcomes and complications following CEA versus CAS over an extended period to identify… read more here.
Keywords: carotid endarterectomy; apc; national inpatient; cas ... See more keywords
Embedded Oxidized Ag-Pd-Cu Ultrathin Metal Alloy Film Prepared at Low Temperature with Excellent Electronic, Optical, and Mechanical Properties.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.1c23766
Abstract: Most transparent conducting materials are based on Sn:In2O3 (ITO). When applied onto flexible substrates, ITO can be prepared in an oxide-metal-oxide (OMO) configuration, typically ITO/Ag/ITO, where the ductility of the embedded metal layer is intended… read more here.
Keywords: conductivity; agglomeration; layer; apc ... See more keywords