The effect of EBV on WIF1, NLK, and APC gene methylation and expression in gastric carcinoma and nasopharyngeal cancer
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Medical Virology"
DOI: 10.1002/jmv.24863
Abstract: Epstein‐Barr virus (EBV) is an important DNA tumor virus that is associated with approximately 10% of gastric carcinomas and 99% of nasopharyngeal cancers (NPC). DNA methylation and microRNAs (miRNAs) are the most studied epigenetic mechanisms… read more here.
Keywords: nlk apc; methylation; apc gene; expression ... See more keywords
A novel large germ line deletion in adenomatous polyposis coli (APC) gene associated with familial adenomatous polyposis
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.479
Abstract: Familial adenomatous polyposis (FAP) is a familial colorectal cancer predisposition syndrome characterized by the development of numerous colorectal polyps, which is inherited in an autosomal dominant manner. FAP is caused by germ line mutations in… read more here.
Keywords: germ line; apc gene; familial adenomatous; polyposis ... See more keywords
Necessity of multiplex ligation probe amplification in genetic tests: Germline variant analysis of the APC gene in familial adenomatous polyposis patients.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer genetics"
DOI: 10.1016/j.cancergen.2022.02.002
Abstract: BACKGROUND Familial adenomatous polyposis (FAP) is an autosomal dominant hereditary cancer syndrome characterized by hundreds to thousands of colorectal adenomatous polyps. Without treatment, progression to colorectal cancer is inevitable. Most pathogenic mutations in the APC… read more here.
Keywords: adenomatous polyposis; probe amplification; familial adenomatous; multiplex ligation ... See more keywords
A novel pathogenic single nucleotide germline deletion in APC gene in a four generation Chinese family with familial adenomatous polyposis
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-10395-x
Abstract: Familial adenomatous polyposis (FAP) is an autosomal dominant precancerous condition which is associated with germline mutations of the APC gene. Clinically, FAP is characterized by the development of multiple colorectal adenomas or polyps which finally… read more here.
Keywords: apc gene; familial adenomatous; family; generation ... See more keywords
O1-15-1Azacytidine is effective in the therapy related myelodysplastic syndrome
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Oncology"
DOI: 10.1093/annonc/mdx697.034
Abstract: The comprehensive genomic analysis by Next generation sequencing can make us find many oncodriver gene mutations. And at the same time, we can find many gene structural mutations outside of oncodriver gene mutations. Most of… read more here.
Keywords: gene mutations; apc gene; case; gene ... See more keywords
miR-155 Is Downregulated in Familial Adenomatous Polyposis and Modulates WNT Signaling by Targeting AXIN1 and TCF4
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-18-0115
Abstract: Adenomatous Polyposis Coli (APC) gene mutations are responsible for the onset of familial adenomatous polyposis (FAP) and sporadic colorectal cancer and have been associated with miRNAs dysregulation. The capacity of miR-155, a cancer-related miRNA, to… read more here.
Keywords: mir 155; apc gene; colorectal cancer; cancer ... See more keywords
Role of a Rare Variant in APC Gene Promoter 1B Region in Classic Familial Adenomatous Polyposis
Sign Up to like & getrecommendations! Published in 2020 at "Digestion"
DOI: 10.1159/000509234
Abstract: Background: Familial adenomatous polyposis (FAP) is most commonly caused by germline variants in the adenomatous polyposis coli (APC) gene. Although definite pathogenic variants could be detected in the majority of individuals with FAP, there are… read more here.
Keywords: promoter region; apc gene; gene; adenomatous polyposis ... See more keywords
Pathogenic APC Variants in Latvian Familial Adenomatous Polyposis Patients
Sign Up to like & getrecommendations! Published in 2019 at "Medicina"
DOI: 10.3390/medicina55100612
Abstract: Background and objectives: Familial adenomatous polyposis is one of the APC-associated polyposis conditions described as genetically predetermined colorectal polyposis syndrome with a variety of symptoms. The purpose of this study was to determine sequence variants… read more here.
Keywords: apc gene; familial adenomatous; variants apc; polyposis ... See more keywords