HER2 and APC Mutations Promote Altered Crypt-Villus Morphology and Marked Hyperplasia in the Intestinal Epithelium
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2021.04.012
Abstract: Background and Aims The Cancer Genome Atlas (TCGA) project has identified HER2 mutations or amplification in 7% of colon cancers. In addition to HER2 mutations, colon cancer patients also possess co-occurring mutations in genes such… read more here.
Keywords: crypt villus; intestinal epithelium; her2 apc; apc mutations ... See more keywords
Neutralizing monoclonal antibody against Dickkopf2 impairs lung cancer progression via activating NK cells
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DOI: 10.1038/s41420-019-0204-4
Abstract: Adenomatous polyposis coli (APC) and KRAS proto-oncogene (KRAS) mutations frequently co-occur in non-small cell lung cancer. Inactivating APC mutations in colorectal carcinoma has been well characterized, leading to the approaches targeting on dysregulated APC pathway.… read more here.
Keywords: apc mutations; antibody; lung cancer; cancer ... See more keywords
Targeted deep sequencing reveals APC mutations as predictors of overall survival in Chinese colorectal patients receiving adjuvant chemotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Scandinavian Journal of Gastroenterology"
DOI: 10.1080/00365521.2021.2022189
Abstract: Abstract Objective: Targeted deep sequencing was used to characterize the mutational spectrum of APC in Chinese colorectal tumors in comparison to that in Caucasians from The Cancer Genome Atlas (TCGA) and to investigate whether APC… read more here.
Keywords: apc mutations; crc; adjuvant chemotherapy; overall survival ... See more keywords
Glutathione Derivatives as Potential Drugs for Colorectal Cancer Resulted by APC Mutations
Sign Up to like & getrecommendations! Published in 2019 at "Research Journal of Pharmacy and Technology"
DOI: 10.5958/0974-360x.2019.00673.5
Abstract: Colorectal cancer is the third most commonly occurring cancer in men and the second most commonly occurring cancer in women.The aim of the present study was to identify the anticolorectal cancer potential of a series… read more here.
Keywords: resulted apc; cancer; glutathione derivatives; derivatives potential ... See more keywords