Mushroom polysaccharides and jiaogulan saponins exert cancer preventive effects by shaping the gut microbiota and microenvironment in ApcMin/+ mice.
Sign Up to like & getrecommendations! Published in 2019 at "Pharmacological research"
DOI: 10.1016/j.phrs.2019.104448
Abstract: The incidence of colorectal cancer (CRC) is alarming among younger peoples. While no effective chemopreventive drug available in the market, researchers have been searching for alternative strategies against CRC that are in demand. Therefore, we… read more here.
Keywords: apcmin mice; gut microbiota; mice; cancer ... See more keywords
Transition state analogue of MTAP extends lifespan of APCMin/+ mice
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-87734-6
Abstract: A mouse model of human Familial Adenomatous Polyposis responds favorably to pharmacological inhibition of 5′-methylthioadenosine phosphorylase (MTAP). Methylthio-DADMe-Immucillin-A (MTDIA) is an orally available, transition state analogue inhibitor of MTAP. 5′-Methylthioadenosine (MTA), the substrate for MTAP,… read more here.
Keywords: mtdia; apcmin mice; mice; state analogue ... See more keywords
Expression of FFAR2 by Dendritic Cells Prevents Their Expression of IL27 and is Required For Maintenance of Mucosal Barrier and Immune Response Against Colorectal Tumors in Mice.
Sign Up to like & getrecommendations! Published in 2020 at "Gastroenterology"
DOI: 10.1053/j.gastro.2019.12.027
Abstract: BACKGROUND & AIMS Intestinal microbes and their metabolites affect development of colorectal cancer (CRC). Short-chain fatty acids are metabolites generated by intestinal microbes from dietary fiber. We investigated the mechanisms by which free fatty acid… read more here.
Keywords: ffar2; il27; colitis; apcmin mice ... See more keywords
Interstitial deletion of the Apc locus in β-catenin-overexpressing cells is a signature of radiation-induced intestinal tumors in C3B6F1 ApcMin/+ mice
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Radiation Research"
DOI: 10.1093/jrr/rrad021
Abstract: Abstract Recent studies have identified interstitial deletions in the cancer genome as a radiation-related mutational signature, although most of them do not fall on cancer driver genes. Pioneering studies in the field have indicated the… read more here.
Keywords: overexpressing cells; radiation induced; radiation; apcmin mice ... See more keywords
Abstract 4244: Black soybean seed coat extract suppress intestinal tumorigenesis in APCmin mice
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4244
Abstract: Background: Colorectal cancer (CRC) is a major cause of cancer-related deaths in Japan and worldwide. Since CRC has been reported to have close relationship with diet, it seems significant to identify dietary constituents that might… read more here.
Keywords: coat extract; intestinal tumorigenesis; mice; seed ... See more keywords
The TLR3/TICAM-1 signal constitutively controls spontaneous polyposis through suppression of c-Myc in ApcMin/+ mice
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biomedical Science"
DOI: 10.1186/s12929-017-0387-z
Abstract: BackgroundIntestinal tumorigenesis is promoted by myeloid differentiation primary response gene 88 (MyD88) activation in response to the components of microbiota in ApcMin/+ mice. Microbiota also contains double-stranded RNA (dsRNA), a ligand for TLR3, which activates… read more here.
Keywords: suppression; ticam1 mice; apcmin mice; mice ... See more keywords
Fucoxanthin Prevents Colorectal Cancer Development in Dextran Sodium Sulfate-treated ApcMin/+ Mice
Sign Up to like & getrecommendations! Published in 2021 at "AntiCancer Research"
DOI: 10.21873/anticanres.14887
Abstract: Background/Aim: A xanthophyll of fucoxanthin (Fx) is a potential chemopreventive agent. Familial adenomatous polyposis (FAP) is an inherited disease that is associated with a high risk of developing colorectal cancer. However, it remains unclear whether… read more here.
Keywords: dextran sodium; colorectal cancer; sodium sulfate; apcmin mice ... See more keywords
Microencapsulated Bifidobacterium bifidum and Lactobacillus gasseri in Combination with Quercetin Inhibit Colorectal Cancer Development in ApcMin/+ Mice
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22094906
Abstract: Recent studies have suggested that flavonoids such as quercetin and probiotics such as Bifidobacterium bifidum (Bf) and Lactobacillus gasseri (Lg) could play a relevant role in inhibiting colon cancer cell growth. Our study investigated the… read more here.
Keywords: cancer; combination quercetin; apcmin mice; quercetin ... See more keywords
In Vivo Metabolite Profiling of DMU-212 in ApcMin/+ Mice Using UHPLC-Q/Orbitrap/LTQ MS
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28093828
Abstract: 3,4,5,4’-Trans-tetramethoxystilbene (Synonyms: DMU-212) is a resveratrol analogue with stronger antiproliferative activity and more bioavailability. However, the metabolite characterization of this component remains insufficient. An efficient strategy was proposed for the comprehensive in vivo metabolite profiling… read more here.
Keywords: orbitrap; dmu 212; metabolite profiling; vivo metabolite ... See more keywords