Calcium‐ and voltage‐driven atrial alternans: Insight from [Ca]i and V m asynchrony
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DOI: 10.14814/phy2.15703
Abstract: Cardiac alternans is defined as beat‐to‐beat alternations in contraction strength, action potential duration (APD), and Ca transient (CaT) amplitude. Cardiac excitation–contraction coupling relies on the activity of two bidirectionally coupled excitable systems, membrane voltage (Vm)… read more here.
Keywords: apd cat; apd alternans; voltage; regulation ... See more keywords
Sensitivity Analysis of Cardiac Alternans and Tachyarrhythmia to Ion Channel Conductance Using Population Modeling
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DOI: 10.3390/bioengineering9110628
Abstract: Action potential duration (APD) alternans, an alternating phenomenon between action potentials in cardiomyocytes, causes heart arrhythmia when the heart rate is high. However, some of the APD alternans observed in clinical trials occurs under slow… read more here.
Keywords: sensitivity; ion channel; apd alternans; population modeling ... See more keywords