Cytoplasmic APE1 promotes resistance response in osteosarcoma patients with cisplatin treatment
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3461
Abstract: Chemotherapy resistance has become a hold back and major clinical challenge in osteosarcoma cancer. The alteration and subcellular distribution of apurinic/apyrimidinic endonuclease 1 (APE1) has been reported to be involved in chemotherapy resistance in many… read more here.
Keywords: chemotherapy; treatment; ape1; cytoplasmic ape1 ... See more keywords
Polyubiquitination of apurinic/apyrimidinic endonuclease 1 by Parkin
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22495
Abstract: Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential protein crucial for repair of oxidized DNA damage not only in genomic DNA but also in mitochondrial DNA. Parkin, a tumor suppressor and Parkinson's disease (PD) associated gene,… read more here.
Keywords: polyubiquitination; ape1; apurinic apyrimidinic; parkin ... See more keywords
Downregulation of APE1 potentiates breast cancer cells to olaparib by inhibiting PARP-1 expression
Sign Up to like & getrecommendations! Published in 2019 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-019-05189-w
Abstract: PurposeTargeting DNA repair mechanisms to induce apoptosis may be a promising strategy for breast cancer treatment. Olaparib is proved to have anticancer effect by inhibiting DNA repairing protein poly (ADP-ribose) polymerase (PARP). However, the cytotoxicity… read more here.
Keywords: olaparib treatment; breast cancer; ape1; parp ... See more keywords
Real-time monitoring and effector screening of APE1 based on rGO assisted DNA nanoprobe.
Sign Up to like & getrecommendations! Published in 2021 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2021.114394
Abstract: Human apurinic/pyrimidine endonuclease 1 (APE1) played a critical role in the occurrence, progress and prognosis of tumors through overexpression and subcellular localization. Thus, it has become an important target for enhancing the sensitivity of tumor… read more here.
Keywords: ape1 activity; ape1; inhibitor; real time ... See more keywords
APE1: A skilled nucleic acid surgeon
Sign Up to like & getrecommendations! Published in 2018 at "DNA Repair"
DOI: 10.1016/j.dnarep.2018.08.012
Abstract: Abstract Before a deleterious DNA lesion can be replaced with its undamaged counterpart, the lesion must first be removed from the genome. This process of removing and replacing DNA lesions is accomplished by the careful… read more here.
Keywords: cleavage; skilled nucleic; ape1; ape1 skilled ... See more keywords
Mechanism of stimulation of DNA binding of the transcription factors by human apurinic/apyrimidinic endonuclease 1, APE1.
Sign Up to like & getrecommendations! Published in 2019 at "DNA repair"
DOI: 10.1016/j.dnarep.2019.102698
Abstract: Aerobic respiration generates reactive oxygen species (ROS), which can damage nucleic acids, proteins and lipids. A number of transcription factors (TFs) contain redox-sensitive cysteine residues at their DNA-binding sites, hence ROS-induced thiol oxidation strongly inhibits… read more here.
Keywords: human apurinic; dna; ape1; apurinic apyrimidinic ... See more keywords
The human AP-endonuclease 1 (APE1) is a DNA G-quadruplex structure binding protein and regulates KRAS expression in pancreatic ductal adenocarcinoma cells.
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic acids research"
DOI: 10.1093/nar/gkac172
Abstract: Pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive types of cancer, is characterized by aberrant activity of oncogenic KRAS. A nuclease-hypersensitive GC-rich region in KRAS promoter can fold into a four-stranded DNA secondary structure… read more here.
Keywords: dna; pancreatic ductal; ape1; structure ... See more keywords
Mechanistic insight into AP-endonuclease 1 cleavage of abasic sites at stalled replication fork mimics.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad481
Abstract: Many types of damage, including abasic sites, block replicative DNA polymerases causing replication fork uncoupling and generating ssDNA. AP-Endonuclease 1 (APE1) has been shown to cleave abasic sites in ssDNA. Importantly, APE1 cleavage of ssDNA… read more here.
Keywords: cleavage; replication fork; ape1; replication ... See more keywords
APE1 assembles biomolecular condensates to promote the ATR–Chk1 DNA damage response in nucleolus
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1101/2022.08.22.504787
Abstract: Multifunctional protein APE1/APEX1/HAP1/Ref-1 (designated as APE1) plays important roles in nuclease-mediated DNA repair and redox regulation in transcription. However, it is unclear how APE1 regulates the DNA damage response (DDR) pathways and influences genome integrity… read more here.
Keywords: ape1; dna damage; atr ddr; ddr ... See more keywords
Oxidative DNA Damage is Concurrently Repaired by BER and APE1-initiated NHEJ in Cortical Neurons.
Sign Up to like & getrecommendations! Published in 2019 at "Neuropathology and applied neurobiology"
DOI: 10.1111/nan.12584
Abstract: AIMS Accumulating studies have suggested that base excision repair (BER) is the major repair pathway of oxidative DNA damage in neurons, and neurons are deficient in other DNA repair pathways, including nucleotide excision repair and… read more here.
Keywords: oxidative dna; dna damage; ape1; repair ... See more keywords
APE1 upregulates MMP-14 via redox-sensitive ARF6-mediated recycling to promote cell invasion of esophageal adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer research"
DOI: 10.1158/0008-5472.can-19-0237
Abstract: Esophageal adenocarcinoma (EAC) is an aggressive malignancy with poor clinical outcome. The incidence of EAC has been rising rapidly in the past three decades. Here, we showed that apurinic/apyrimidinic endonuclease (APE1) is overexpressed in EAC… read more here.
Keywords: redox; mmp; invasion; cell ... See more keywords