miR‐497 accelerates oxidized low‐density lipoprotein‐induced lipid accumulation in macrophages by repressing the expression of apelin
Sign Up to like & getrecommendations! Published in 2017 at "Cell Biology International"
DOI: 10.1002/cbin.10808
Abstract: microRNAs (miRNAs) play important roles in the pathogenesis of atherosclerosis. A previous study has reported that miR‐497 is elevated in advanced atherosclerotic lesions in an apoE‐deficient (apoE‐/‐) mouse model. The purpose of this study is… read more here.
Keywords: lipid accumulation; apelin; mir; mir 497 ... See more keywords
The Apelin–Apelin Receptor Axis Triggers Cholangiocyte Proliferation and Liver Fibrosis During Mouse Models of Cholestasis
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31545
Abstract: Apelin (APLN) is the endogenous ligand of its G protein–coupled receptor, apelin receptor (APJ). APLN serum levels are increased in human liver diseases. We evaluated whether the APLN–APJ axis regulates ductular reaction and liver fibrosis… read more here.
Keywords: liver fibrosis; axis; apelin; receptor ... See more keywords
Apelin/APJ system: A novel promising target for neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29001
Abstract: Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD), are incurable diseases characterized by progressive loss of cognitive or motor function, which construct a serious threat to the life quality of… read more here.
Keywords: apelin apj; apelin; apj system; target ... See more keywords
The G protein‐coupled receptor ligand apelin‐13 ameliorates skeletal muscle atrophy induced by chronic kidney disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13159
Abstract: Targeting of the apelin–apelin receptor (Apj) system may serve as a useful therapeutic intervention for the management of chronic kidney disease (CKD)‐induced skeletal muscle atrophy. We investigated the roles and efficacy of the apelin–Apj system… read more here.
Keywords: apelin; chronic kidney; muscle; muscle atrophy ... See more keywords
Effect of Intracerebroventricular Administration of Apelin-13 on the Hypothalamus–Pituitary–Thyroid Axis and Peripheral Uncoupling Proteins
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-017-9638-9
Abstract: Apelin, a ligand for G protein-coupled APJ receptor, is a peptide hormone. Although apelin and APJ receptors are determined in hypothalamus and thyroid gland its role in the hypothalamus–pituitary–thyroid (HPT) axis and mechanism of action… read more here.
Keywords: apelin; group; hpt axis; hypothalamus pituitary ... See more keywords
Apelin abrogates the stimulatory effects of 17β-estradiol and insulin-like growth factor-1 on proliferation of epithelial and granulosa ovarian cancer cell lines via crosstalk between APLNR and ERα/IGF1R
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology Reports"
DOI: 10.1007/s11033-019-05073-2
Abstract: Apelin and chemerin are adipocytokines that play important roles in many physiological and pathological processes throughout the body. Our previous study demonstrated that these two adipokines are expressed and secreted by epithelial and granulosa cancer… read more here.
Keywords: granulosa; apelin; cell lines; proliferation ... See more keywords
Acylated apelin‐13 amide analogues exhibit enzyme resistance and prolonged insulin releasing, glucose lowering and anorexic properties
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2017.10.002
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT The adipokine, apelin has many biological functions but its activity is curtailed by rapid plasma degradation. Fatty acid derived apelin analogues represent a new and exciting avenue for… read more here.
Keywords: insulin; apelin; lys8glupal apelin; pglu lys8glupal ... See more keywords
Plasma Apelin Concentration in Exercised Horses: Preliminary Study.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of equine veterinary science"
DOI: 10.1016/j.jevs.2019.06.012
Abstract: Physical effort is one of the key aspects of keeping horses in good condition. The condition of the animal is reflected by multiple blood parameters. The newly discovered cytokine-apelin can pose one of them, however,… read more here.
Keywords: apelin concentration; plasma apelin; apelin; study ... See more keywords
Apelin-13 Upregulates BDNF Against Chronic Stress-induced Depression-like Phenotypes by Ameliorating HPA Axis and Hippocampal Glucocorticoid Receptor Dysfunctions
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2018.08.018
Abstract: Localization of apelin and its receptor APJ in limbic structures such as the hippocampus suggests potential involvement of apelin/APJ signaling in stress-related emotional responses. We have recently reported that apelin-13 exerts antidepressant-like actions in acute… read more here.
Keywords: like phenotypes; apelin; stress; receptor ... See more keywords
Apelin-13 analogues show potent in vitro and in vivo insulinotropic and glucose lowering actions
Sign Up to like & getrecommendations! Published in 2018 at "Peptides"
DOI: 10.1016/j.peptides.2017.12.004
Abstract: HighlightsN‐ and C‐terminally structurally modified peptide analogues of apelin‐13 are more stable than the native peptide and retain bioactivity.Apelin‐13 analogues produce a strong dose‐dependent insulinotropic response in cultured pancreatic BRIN‐BD11 cells and isolated mouse islets.Apelin‐13… read more here.
Keywords: apelin; bd11 cells; apelin analogues; brin bd11 ... See more keywords
MiR-503 suppresses hypoxia-induced proliferation, migration and angiogenesis of endothelial progenitor cells by targeting Apelin
Sign Up to like & getrecommendations! Published in 2018 at "Peptides"
DOI: 10.1016/j.peptides.2018.05.008
Abstract: HighlightsMiR‐503 suppresses hypoxia‐induced proliferation, migration and angiogenesis of endothelial progenitor cells.MiR‐503 directly targets to Apelin via its 3′‐UTR region in EPCs.Increased expression of Apelin promotes EPC growth, migration and angiogenesis under hypoxia. ABSTRACT Endothelial progenitor… read more here.
Keywords: proliferation migration; migration angiogenesis; mir 503; apelin ... See more keywords