Apelin-13 analogues show potent in vitro and in vivo insulinotropic and glucose lowering actions
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DOI: 10.1016/j.peptides.2017.12.004
Abstract: HighlightsN‐ and C‐terminally structurally modified peptide analogues of apelin‐13 are more stable than the native peptide and retain bioactivity.Apelin‐13 analogues produce a strong dose‐dependent insulinotropic response in cultured pancreatic BRIN‐BD11 cells and isolated mouse islets.Apelin‐13… read more here.
Keywords: apelin; bd11 cells; apelin analogues; brin bd11 ... See more keywords
Long-term treatment with acylated analogues of apelin-13 amide ameliorates diabetes and improves lipid profile of high-fat fed mice
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DOI: 10.1371/journal.pone.0202350
Abstract: Previous studies have shown that modified apelin analogues exhibited enzyme resistance in plasma and improved circulating half-life compared to apelin-13. This study investigated the antidiabetic effects of chronic administration of stable long acting fatty acid… read more here.
Keywords: apelin; lys8glupal apelin; apelin analogues; high fat ... See more keywords