Apelin/APJ system: A novel potential therapy target for kidney disease
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DOI: 10.1002/jcp.26144
Abstract: Apelin is an endogenous ligand of seven‐transmembrane G protein‐coupled receptor APJ. Apelin and APJ are distributed in various tissues, including the heart, lung, kidney, and even in tumor tissues. Studies show that apelin mRNA is… read more here.
Keywords: apelin apj; apj system; kidney;
Function and regulation of apelin/APJ system in digestive physiology and pathology
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27720
Abstract: Apelin is an endogenous ligand of seven‐transmembrane G‐protein‐coupled receptor APJ. Apelin and APJ are distributed in various tissues, including the heart, lung, liver, kidney, and gastrointestinal tract and even in tumor tissues. Studies show that… read more here.
Keywords: apelin apj; physiology; apj system; pathology ... See more keywords
Apelin/APJ system: A novel promising target for neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29001
Abstract: Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD), are incurable diseases characterized by progressive loss of cognitive or motor function, which construct a serious threat to the life quality of… read more here.
Keywords: apelin apj; apelin; apj system; target ... See more keywords
Roles of apelin/APJ system in cancer: Biomarker, predictor, and emerging therapeutic target
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30845
Abstract: Cancer is a disease that seriously endangers human health and is mainly characterized by a high metastasis rate, a high recurrence rate, and a high mortality rate. The treatment of cancer has always been an… read more here.
Keywords: apj system; biomarker predictor; apelin apj; cancer ... See more keywords
The apelin/APJ system as a therapeutic target in metabolic diseases
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2019.1561871
Abstract: ABSTRACT Introduction: Apelin, a bioactive peptide, is the endogenous ligand of APJ, a G protein-coupled receptor which is widely expressed in peripheral tissues and in the central nervous system. The apelin/APJ system is involved in… read more here.
Keywords: apelin apj; metabolic diseases; apj system; apj ... See more keywords
Fucoxanthin alters the apelin-13/APJ pathway in certain organs of γ-irradiated mice
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DOI: 10.1093/jrr/rraa141
Abstract: Abstract Apelin-13 and APJ are implicated in different key physiological processes. This work aims at exploring the radioprotective effect of fucoxanthin (FX) on γ-radiation (RAD)-induced changes in the apelin-13/APJ pathway, which causes damage in the… read more here.
Keywords: apj pathway; apelin apj; fucoxanthin alters; irradiated mice ... See more keywords
A9461 Associations between gene polymorphisms of the apelin–APJ system and the risk of hypertension
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000549278.82298.c9
Abstract: Objectives: In the present study, we determined the genotypes of three apelin gene SNPs, namely rs3115757, rs56204867 and rs3761581, as well as two APJ gene SNPs, namely rs7119375 and rs9943582, to assess the associations between… read more here.
Keywords: apelin apj; gene; gene snps; hypertension ... See more keywords
A13320 Associations between gene polymorphisms of the apelin-APJ system and hypertensive vascular damage
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DOI: 10.1097/01.hjh.0000549337.01156.c5
Abstract: Objectives: The aim of this study was to investigate the association of apelin-APJ patyway single nucleotide and hypertensive vascular damage through brachial ankle pulse wave velocity (baPWV). Methods: A total of 556 hypertensive subjects, including… read more here.
Keywords: hypertensive vascular; apelin apj; arterial stiffness; bapwv ... See more keywords
Apelin-13/APJ system delays intervertebral disc degeneration by activating the PI3K/AKT signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202003_20643
Abstract: OBJECTIVE To study the effect of Apelin-13/APJ system on intervertebral disc degeneration and its mechanism. PATIENTS AND METHODS This study detected the expression of APJ in human intervertebral disc tissue with varying degrees of degeneration.… read more here.
Keywords: apelin apj; apj system; pi3k akt; nucleus pulposus ... See more keywords
The beneficial roles of apelin-13/APJ system in cerebral ischemia: Pathogenesis and therapeutic strategies
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DOI: 10.3389/fphar.2022.903151
Abstract: The incidence of cerebral ischemia has increased in the past decades, and the high fatality and disability rates seriously affect human health. Apelin is a bioactive peptide and the ligand of the G protein-coupled receptor… read more here.
Keywords: ischemia; roles apelin; cerebral ischemia; apelin apj ... See more keywords