The Apelin–Apelin Receptor Axis Triggers Cholangiocyte Proliferation and Liver Fibrosis During Mouse Models of Cholestasis
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31545
Abstract: Apelin (APLN) is the endogenous ligand of its G protein–coupled receptor, apelin receptor (APJ). APLN serum levels are increased in human liver diseases. We evaluated whether the APLN–APJ axis regulates ductular reaction and liver fibrosis… read more here.
Keywords: liver fibrosis; axis; apelin; receptor ... See more keywords
Inducible apelin receptor knockdown reduces differentiation efficiency and contractility of hESC-derived cardiomyocytes
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DOI: 10.1093/cvr/cvac065
Abstract: Abstract Aims The apelin receptor, a G protein-coupled receptor, has emerged as a key regulator of cardiovascular development, physiology, and disease. However, there is a lack of suitable human in vitro models to investigate the… read more here.
Keywords: receptor knockdown; apelin receptor; hesc; heart ... See more keywords
Expanding the apelin receptor pharmacological toolbox using novel fluorescent ligands
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1139121
Abstract: Introduction The apelin receptor binds two distinct endogenous peptides, apelin and ELA, which act in an autocrine/paracrine manner to regulate the human cardiovascular system. As a class A GPCR, targeting the apelin receptor is an… read more here.
Keywords: fluorescent ligands; apelin receptor; pharmacological toolbox; receptor ... See more keywords
Cancer apelin receptor suppresses vascular mimicry in malignant melanoma
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DOI: 10.3389/pore.2023.1610867
Abstract: Several reports indicate that apelin is often over-expressed in tumors, and therefore it has been suggested that the apelin–apelin receptor (APJ) system may induce tumor progression. In contrast, our previous research revealed high expression of… read more here.
Keywords: melanoma; growth; apelin; apelin receptor ... See more keywords