Interaction between the apelinergic system and ACE2 in the cardiovascular system: therapeutic implications.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical science"
DOI: 10.1042/cs20200479
Abstract: The apelinergic system is widely expressed and acts through autocrine and paracrine signaling to exert protective effects, including vasodilatory, metabolic, and inotropic effects on the cardiovascular (CV) system. The apelin pathway's dominant physiological role has… read more here.
Keywords: system; therapeutic implications; apelin peptides; interaction ... See more keywords
The apelinergic system: a perspective on challenges and opportunities in cardiovascular and metabolic disorders
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the New York Academy of Sciences"
DOI: 10.1111/nyas.14123
Abstract: The apelinergic pathway has been generating increasing interest in the past few years for its potential as a therapeutic target in several conditions associated with the cardiovascular and metabolic systems. Indeed, preclinical and, more recently,… read more here.
Keywords: challenges opportunities; system; cardiovascular metabolic; apelinergic system ... See more keywords
Apelinergic system in the kidney: implications for diabetic kidney disease
Sign Up to like & getrecommendations! Published in 2018 at "Physiological Reports"
DOI: 10.14814/phy2.13939
Abstract: The bioactive peptides of the apelinergic system and its receptor APJ have been shown to play a protective role in experimental cardiovascular and diabetic kidney disease (DKD). Mechanisms of this renoprotective effect remain to be… read more here.
Keywords: apelinergic system; diabetic kidney; kidney disease; kidney ... See more keywords
Effect of SARS-CoV-2 Infection on Selected Parameters of the Apelinergic System in Repeat Blood Donors
Sign Up to like & getrecommendations! Published in 2024 at "Biomedicines"
DOI: 10.3390/biomedicines12112583
Abstract: Background: SARS-CoV-2 enters cells primarily by binding to the angiotensin-converting enzyme 2 (ACE2) receptor, thereby blocking its physiological functions, affecting the apelinergic system, and inhibiting the cleavage of its peptides. The appropriate concentration of peptides… read more here.
Keywords: sars cov; apelinergic system; cov infection; infection ... See more keywords
Apelinergic System Affects Electrocardiographic Abnormalities Induced by Doxorubicin
Sign Up to like & getrecommendations! Published in 2025 at "Biomedicines"
DOI: 10.3390/biomedicines13010094
Abstract: Background/Objectives: Anthracyclines remain a pivotal element of numerous tumor management regimens; however, their utilization is associated with a range of adverse effects, the most significant of which is cardiotoxicity. Research is constantly being conducted to… read more here.
Keywords: system affects; system; electrocardiographic abnormalities; apelinergic system ... See more keywords
Distribution, Function, and Expression of the Apelinergic System in the Healthy and Diseased Mammalian Brain
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13112172
Abstract: Apelin, a peptide initially isolated from bovine stomach extract, is an endogenous ligand for the Apelin Receptor (APLNR). Subsequently, a second peptide, ELABELA, that can bind to the receptor has been identified. The Apelin receptor… read more here.
Keywords: system; apelinergic system; brain; distribution function ... See more keywords