Interaction between the apelinergic system and ACE2 in the cardiovascular system: therapeutic implications.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical science"
DOI: 10.1042/cs20200479
Abstract: The apelinergic system is widely expressed and acts through autocrine and paracrine signaling to exert protective effects, including vasodilatory, metabolic, and inotropic effects on the cardiovascular (CV) system. The apelin pathway's dominant physiological role has… read more here.
Keywords: system; therapeutic implications; apelin peptides; interaction ... See more keywords
The apelinergic system: a perspective on challenges and opportunities in cardiovascular and metabolic disorders
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the New York Academy of Sciences"
DOI: 10.1111/nyas.14123
Abstract: The apelinergic pathway has been generating increasing interest in the past few years for its potential as a therapeutic target in several conditions associated with the cardiovascular and metabolic systems. Indeed, preclinical and, more recently,… read more here.
Keywords: challenges opportunities; system; cardiovascular metabolic; apelinergic system ... See more keywords
Apelinergic system in the kidney: implications for diabetic kidney disease
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DOI: 10.14814/phy2.13939
Abstract: The bioactive peptides of the apelinergic system and its receptor APJ have been shown to play a protective role in experimental cardiovascular and diabetic kidney disease (DKD). Mechanisms of this renoprotective effect remain to be… read more here.
Keywords: apelinergic system; diabetic kidney; kidney disease; kidney ... See more keywords
Distribution, Function, and Expression of the Apelinergic System in the Healthy and Diseased Mammalian Brain
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DOI: 10.3390/genes13112172
Abstract: Apelin, a peptide initially isolated from bovine stomach extract, is an endogenous ligand for the Apelin Receptor (APLNR). Subsequently, a second peptide, ELABELA, that can bind to the receptor has been identified. The Apelin receptor… read more here.
Keywords: system; apelinergic system; brain; distribution function ... See more keywords