A novel SMAC mimetic APG‐1387 exhibits dual antitumor effect on HBV‐positive hepatocellular carcinoma with high expression of cIAP2 by inducing apoptosis and enhancing innate anti‐tumor immunity
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.04.020
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT Check point inhibitor anti‐PD1 antibody produced some efficacy in Hepatocellular Carcinoma (HCC) patients previously treated with sorafenib. Unfortunately, HCC patients with hepatitis B virus (HBV) infection did not… read more here.
Keywords: hepatocellular carcinoma; hbv positive; apoptosis; expression ... See more keywords
Targeting cIAPs attenuates CCl4-induced liver fibrosis by increasing MMP9 expression derived from neutrophils.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.120235
Abstract: AIMS Liver fibrosis is a growing public health concern without effective medical treatment. Recent reports have indicated that inhibitors of apoptosis proteins (IAPs) were potential targets for idiopathic pulmonary fibrosis therapy. However, their roles have… read more here.
Keywords: ccl4 induced; expression; apg 1387; liver fibrosis ... See more keywords
A phase I study of a novel IAP inhibitor APG-1387 as a monotherapy or in combination with pembrolizumab in treatments of patients with advanced solid tumors.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.3125
Abstract: 3125 Background: APG-1387 is a novel, bivalent small molecule IAP (inhibitor of apoptosis proteins) inhibitor. It has shown strong antitumor activities in multiple human xenograft cancer models. APG-1387 also acts as host immune modulator, supporting… read more here.
Keywords: combination pembrolizumab; apg; apg 1387; study ... See more keywords