Specific Mutations in Aph1 Cause γ-Secretase Activation
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DOI: 10.3390/ijms23010507
Abstract: Amyloid beta peptides (Aβs) are generated from amyloid precursor protein (APP) through multiple cleavage steps mediated by γ-secretase, including endoproteolysis and carboxypeptidase-like trimming. The generation of neurotoxic Aβ42/43 species is enhanced by familial Alzheimer’s disease… read more here.
Keywords: function; aph1 cause; fad mutations; secretase ... See more keywords