Cholesterol-rich domain formation mediated by ZO proteins is essential for tight junction formation.
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DOI: 10.1073/pnas.2217561120
Abstract: Tight junctions (TJs) are cell-adhesion structures responsible for the epithelial barrier. We reported that accumulation of cholesterol at the apical junctions is required for TJ formation [K. Shigetomi, Y. Ono, T. Inai, J. Ikenouchi, J.… read more here.
Keywords: apical junctions; cholesterol rich; rich domain; formation cholesterol ... See more keywords