Basolateral cholesterol depletion alters Aquaporin-2 post-translational modifications and disrupts apical plasma membrane targeting.
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DOI: 10.1016/j.bbrc.2017.11.002
Abstract: Apical plasma membrane accumulation of the water channel Aquaporin-2 (AQP2) in kidney collecting duct principal cells is critical for body water homeostasis. Posttranslational modification (PTM) of AQP2 is important for regulating AQP2 trafficking. The aim… read more here.
Keywords: cholesterol; membrane targeting; apical plasma; membrane ... See more keywords