Division and Adaptation to Host Environment of Apicomplexan Parasites Depend on Apicoplast Lipid Metabolic Plasticity and Host Organelle Remodeling.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.02.072
Abstract: Apicomplexan parasites are unicellular eukaryotic pathogens that must obtain and combine lipids from both host cell scavenging and de novo synthesis to maintain parasite propagation and survival within their human host. Major questions on the… read more here.
Keywords: plasticity; host; novo synthesis; apicomplexan parasites ... See more keywords
Phosphoinositides and their functions in apicomplexan parasites.
Sign Up to like & getrecommendations! Published in 2018 at "International journal for parasitology"
DOI: 10.1016/j.ijpara.2018.01.009
Abstract: Phosphoinositides are the phosphorylated derivatives of the structural membrane phospholipid phosphatidylinositol. Single or combined phosphorylation at the 3, 4 and 5 positions of the inositol ring gives rise to the seven different species of phosphoinositides.… read more here.
Keywords: parasitology; biology; functions apicomplexan; phosphoinositides functions ... See more keywords
Target Identification of an Antimalarial Oxaborole Identifies AN13762 as an Alternative Chemotype for Targeting CPSF3 in Apicomplexan Parasites
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.101871
Abstract: Summary Boron-containing compounds represent a promising class of molecules with proven efficacy against a wide range of pathogens, including apicomplexan parasites. Following lead optimization, the benzoxaborole AN13762 was identified as a preclinical candidate against the… read more here.
Keywords: identification antimalarial; oxaborole identifies; target identification; identifies an13762 ... See more keywords
Translational Control in the Latency of Apicomplexan Parasites.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in parasitology"
DOI: 10.1016/j.pt.2017.08.006
Abstract: Apicomplexan parasites Toxoplasma gondii and Plasmodium spp. use latent stages to persist in the host, facilitate transmission, and thwart treatment of infected patients. Therefore, it is important to understand the processes driving parasite differentiation to… read more here.
Keywords: control; control latency; translational control; apicomplexan parasites ... See more keywords
The Riveting Cellular Structures of Apicomplexan Parasites.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in parasitology"
DOI: 10.1016/j.pt.2020.09.001
Abstract: Parasitic protozoa of the phylum Apicomplexa cause a range of human and animal diseases. Their complex life cycles - often heteroxenous with sexual and asexual phases in different hosts - rely on elaborate cytoskeletal structures… read more here.
Keywords: riveting cellular; structures apicomplexan; cellular structures; biology ... See more keywords
A toolbox for conditional control of gene expression in apicomplexan parasites.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular microbiology"
DOI: 10.1111/mmi.14821
Abstract: Apicomplexan parasites encompass diverse pathogens for humans and animals, including the causative agents of malaria and toxoplasmosis, Plasmodium spp. and Toxoplasma gondii. Genetic manipulation of these parasites has become central to explore parasite biology, unravel… read more here.
Keywords: conditional control; gene expression; expression; control gene ... See more keywords
Characterisation of the OTU domain deubiquitinase complement of Toxoplasma gondii
Sign Up to like & getrecommendations! Published in 2023 at "Life Science Alliance"
DOI: 10.26508/lsa.202201710
Abstract: The OTU deubiquitinase family is expanded in Toxoplasma parasites, and members show preferences for Lys6-, Lys11-, Lys48-, and Lys63-linked ubiquitin chains, and additional specificity for NEDD8. AlphaFold-guided structural analysis reveals cryptic ubiquitin-binding domains with functional… read more here.
Keywords: otu; apicomplexan parasites; characterisation; toxoplasma ... See more keywords
Bioactive Peptides against Human Apicomplexan Parasites
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DOI: 10.3390/antibiotics11111658
Abstract: Apicomplexan parasites are the causal agents of different medically important diseases, such as toxoplasmosis, cryptosporidiosis, and malaria. Toxoplasmosis is considered a neglected parasitosis, even though it can cause severe cerebral complications and death in immunocompromised… read more here.
Keywords: bioactive peptides; human apicomplexan; apicomplexan parasites; peptides human ... See more keywords
Pinniped- and Cetacean-Derived ETosis Contributes to Combating Emerging Apicomplexan Parasites (Toxoplasma gondii, Neospora caninum) Circulating in Marine Environments
Sign Up to like & getrecommendations! Published in 2019 at "Biology"
DOI: 10.3390/biology8010012
Abstract: Leukocytes play a major role in combating infections either by phagocytosis, release of antimicrobial granules, or extracellular trap (ET) formation. ET formation is preceded by a certain leukocyte cell death form, known as ETosis, an… read more here.
Keywords: etosis; pinniped cetacean; parasites toxoplasma; toxoplasma gondii ... See more keywords
Protein Import into the Endosymbiotic Organelles of Apicomplexan Parasites
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DOI: 10.3390/genes9080412
Abstract: The organelles of endosymbiotic origin, plastids, and mitochondria, evolved through the serial acquisition of endosymbionts by a host cell. These events were accompanied by gene transfer from the symbionts to the host, resulting in most… read more here.
Keywords: organelles apicomplexan; protein import; import endosymbiotic; endosymbiotic organelles ... See more keywords
Amino Acid Metabolism in Apicomplexan Parasites
Sign Up to like & getrecommendations! Published in 2021 at "Metabolites"
DOI: 10.3390/metabo11020061
Abstract: Obligate intracellular pathogens have coevolved with their host, leading to clever strategies to access nutrients, to combat the host’s immune response, and to establish a safe niche for intracellular replication. The host, on the other… read more here.
Keywords: metabolism apicomplexan; amino acids; amino acid; acid metabolism ... See more keywords