Apigenin inhibits isoproterenol‐induced myocardial fibrosis and Smad pathway in mice by regulating oxidative stress and miR‐122‐5p/155‐5p expressions
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21928
Abstract: Apigenin, a flavonoid isolated from Apium graveolens, is an effective natural active ingredient that inhibits transforming growth factor‐β1 (TGF‐β1)‐induced cardiac fibroblasts (CFs) differentiation and collagen synthesis. However, its effects on isoproterenol‐induced myocardial fibrosis in mice… read more here.
Keywords: apigenin; myocardial fibrosis; mir 122; mice ... See more keywords
Apigenin suppresses influenza A virus‐induced RIG‐I activation and viral replication
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Medical Virology"
DOI: 10.1002/jmv.26403
Abstract: Apigenin is a flavonoid of low toxicity and multiple beneficial bioactivities, including the properties of antitumor, antioxidant, anti‐inflammatory, and antiviral activities. However, the effects of Apigenin on influenza virus infection remain poorly understood. Thus, the… read more here.
Keywords: viral replication; apigenin; activation; influenza virus ... See more keywords
Inhibition of MDA‐MB‐231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation‐mediated p21WAF1/CIP1 expression
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Toxicology"
DOI: 10.1002/tox.22247
Abstract: Apigenin (4′,5,7‐trihydroxyflavone), a flavonoid commonly found in fruits and vegetables, has anticancer properties in various malignant cancer cells. However, the molecular basis of the anticancer effect remains to be elucidated. In this study, we investigated… read more here.
Keywords: p21waf1 cip1; apigenin; breast cancer; cell ... See more keywords
Protective Effect of Apigenin on Acrylonitrile-Induced Inflammation and Apoptosis in Testicular Cells via the NF-κB Pathway in Rats
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation"
DOI: 10.1007/s10753-018-0791-x
Abstract: Apigenin (AP) as a plant flavonoid is found to attenuate acrylonitrile (ACN) toxicity by reducing ROS production and inhibiting apoptosis. Therefore, the present study aimed to evaluate the role of AP on ACN-induced inflammation and… read more here.
Keywords: induced inflammation; apoptosis; apigenin; inflammation ... See more keywords
The natural flavones, acacetin and apigenin, induce Cdk-Cyclin mediated G2/M phase arrest and trigger ROS-mediated apoptosis in glioblastoma cells
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Biology Reports"
DOI: 10.1007/s11033-020-06087-x
Abstract: Brain and CNS-related cancers are rare; however, 0.3 million incidences and 0.24 million deaths in 2018 demonstrates the unrelenting associated dangers. Glioblastoma is a brain cancer of star-shaped glial cells. It is almost universally fatal within… read more here.
Keywords: apoptosis; apigenin; phase arrest; acacetin apigenin ... See more keywords
Ecophysiological, anatomical, and apigenin changes due to uptake and accumulation of cadmium in Matricaria chamomilla L. flowers in hydroponics
Sign Up to like & getrecommendations! Published in 2021 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-021-14000-7
Abstract: Cadmium (Cd) is one of the most important heavy metals in the environment which has several effects on the morphology, physiology, and anatomy of plants. It is a mobile heavy metal that can be transferred… read more here.
Keywords: apigenin; ecophysiological anatomical; cadmium; matricaria chamomilla ... See more keywords
Apigenin increases radiosensitivity of glioma stem cells by attenuating HIF-1α-mediated glycolysis
Sign Up to like & getrecommendations! Published in 2021 at "Medical Oncology"
DOI: 10.1007/s12032-021-01586-8
Abstract: Apigenin, a natural flavonoid compound present in a variety of edible plants and health foods, has an anti-tumor effect and inhibits hypoxia inducible factor-lα (HIF-1α) expression in hypertrophic cardiac tissues. However, whether or not apigenin… read more here.
Keywords: hif; glioma stem; apigenin; expression ... See more keywords
Isolation, identification and characterization of apigenin from Justicia gendarussa and its anti‐inflammatory activity
Sign Up to like & getrecommendations! Published in 2018 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2018.04.004
Abstract: ABSTRACT Inflammatory responses during chronic diseases such as atherosclerosis, cancer etc., are harmful to host organisms. Generally NSAIDs are used to treat against these severe conditions but due to its adverse effects studies are going… read more here.
Keywords: anti inflammatory; apigenin; justicia gendarussa; isolation ... See more keywords
Enhanced chemotherapeutic efficacy of apigenin liposomes in colorectal cancer based on flavone-membrane interactions.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of colloid and interface science"
DOI: 10.1016/j.jcis.2016.12.025
Abstract: Recent endeavors in exploiting vast array of natural phytochemicals to ameliorate colorectal cancer led us to investigate apigenin, a naturally occurring dietary flavone as a potential chemo-therapeutic agent. The present study focuses on establishing apigenin… read more here.
Keywords: chemotherapeutic efficacy; apigenin; colorectal cancer; efficacy apigenin ... See more keywords
Apigenin attenuates doxorubicin induced cardiotoxicity via reducing oxidative stress and apoptosis in male rats.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.116623
Abstract: AIMS Doxorubicin, an antibiotic belonging to anthracycline family, has been used for treatment of malignancies. Cardiotoxicity is the main adverse effect of doxorubicin. Apigenin, as a flavonoid, has antioxidant, anti-inflammatory and anti-tumoral properties. The aim… read more here.
Keywords: apoptosis; apigenin; dox api; cardiotoxicity ... See more keywords
Apigenin attenuates patulin‐induced apoptosis in HEK293 cells by modulating ROS‐mediated mitochondrial dysfunction and caspase signal pathway
Sign Up to like & getrecommendations! Published in 2017 at "Toxicon"
DOI: 10.1016/j.toxicon.2017.07.018
Abstract: ABSTRACT Mycotoxins like patulin (PAT) are among the most significant food contaminant with regard to public health. This study aimed to evaluate the protective effect of apigenin (API), one of the most bioactive flavonoids in… read more here.
Keywords: patulin induced; ros mediated; apigenin; apoptosis hek293 ... See more keywords