Blood vessels sense dermal stiffness via a novel mechanotransducer, APJ.
Sign Up to like & getrecommendations! Published in 2021 at "Angiogenesis"
DOI: 10.1007/s10456-021-09821-6
Abstract: Microvascular dysfunction accompanied by a dramatic alteration of stable capillary structure is a major hallmark of numerous age-related diseases. In skin, although the role of angiogenesis during dermal reconstitution is well documented, the functional relevance… read more here.
Keywords: blood vessels; apj; stiffness; novel mechanotransducer ... See more keywords
The apelin/APJ system as a therapeutic target in metabolic diseases
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2019.1561871
Abstract: ABSTRACT Introduction: Apelin, a bioactive peptide, is the endogenous ligand of APJ, a G protein-coupled receptor which is widely expressed in peripheral tissues and in the central nervous system. The apelin/APJ system is involved in… read more here.
Keywords: apelin apj; metabolic diseases; apj system; apj ... See more keywords
Investigation into the role of Apj and Vegf receptor signaling in the regulation of coronary angiogenesis
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5791130
Abstract: Coronary artery disease (CAD) is one of the leading causes of death worldwide; however, a therapeutic remedy has not been developed. Coronary angiogenesis, a process by which new coronary vessels are formed in the embryos,… read more here.
Keywords: endothelial cells; physiology; apj; receptor ... See more keywords
Cancer apelin receptor suppresses vascular mimicry in malignant melanoma
Sign Up to like & getrecommendations! Published in 2023 at "Pathology and Oncology Research"
DOI: 10.3389/pore.2023.1610867
Abstract: Several reports indicate that apelin is often over-expressed in tumors, and therefore it has been suggested that the apelin–apelin receptor (APJ) system may induce tumor progression. In contrast, our previous research revealed high expression of… read more here.
Keywords: melanoma; growth; apelin; apelin receptor ... See more keywords