Apelin/APJ system: A novel potential therapy target for kidney disease
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DOI: 10.1002/jcp.26144
Abstract: Apelin is an endogenous ligand of seven‐transmembrane G protein‐coupled receptor APJ. Apelin and APJ are distributed in various tissues, including the heart, lung, kidney, and even in tumor tissues. Studies show that apelin mRNA is… read more here.
Keywords: apelin apj; apj system; kidney;
Function and regulation of apelin/APJ system in digestive physiology and pathology
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DOI: 10.1002/jcp.27720
Abstract: Apelin is an endogenous ligand of seven‐transmembrane G‐protein‐coupled receptor APJ. Apelin and APJ are distributed in various tissues, including the heart, lung, liver, kidney, and gastrointestinal tract and even in tumor tissues. Studies show that… read more here.
Keywords: apelin apj; physiology; apj system; pathology ... See more keywords
Apelin/APJ system: A novel promising target for neurodegenerative diseases
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DOI: 10.1002/jcp.29001
Abstract: Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD), are incurable diseases characterized by progressive loss of cognitive or motor function, which construct a serious threat to the life quality of… read more here.
Keywords: apelin apj; apelin; apj system; target ... See more keywords
Roles of apelin/APJ system in cancer: Biomarker, predictor, and emerging therapeutic target
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DOI: 10.1002/jcp.30845
Abstract: Cancer is a disease that seriously endangers human health and is mainly characterized by a high metastasis rate, a high recurrence rate, and a high mortality rate. The treatment of cancer has always been an… read more here.
Keywords: apj system; biomarker predictor; apelin apj; cancer ... See more keywords
The apelin/APJ system as a therapeutic target in metabolic diseases
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DOI: 10.1080/14728222.2019.1561871
Abstract: ABSTRACT Introduction: Apelin, a bioactive peptide, is the endogenous ligand of APJ, a G protein-coupled receptor which is widely expressed in peripheral tissues and in the central nervous system. The apelin/APJ system is involved in… read more here.
Keywords: apelin apj; metabolic diseases; apj system; apj ... See more keywords
Apelin-13/APJ system delays intervertebral disc degeneration by activating the PI3K/AKT signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202003_20643
Abstract: OBJECTIVE To study the effect of Apelin-13/APJ system on intervertebral disc degeneration and its mechanism. PATIENTS AND METHODS This study detected the expression of APJ in human intervertebral disc tissue with varying degrees of degeneration.… read more here.
Keywords: apelin apj; apj system; pi3k akt; nucleus pulposus ... See more keywords