Serological evolution in women with positive antiphospholipid antibodies.
Sign Up to like & getrecommendations! Published in 2017 at "Seminars in arthritis and rheumatism"
DOI: 10.1016/j.semarthrit.2017.05.001
Abstract: OBJECTIVES To explore the clinical and serological course of fertile women with positive antiphospholipid (aPL), and the factors and therapeutic implications associated with aPL negativization. METHODS Retrospective study including 105 women with a positive aPL… read more here.
Keywords: women positive; serology; apl serology; apl ... See more keywords
Deneddylation of PML/RARα reconstructs functional PML nuclear bodies via orchestrating phase separation to eradicate APL.
Sign Up to like & getrecommendations! Published in 2022 at "Cell death and differentiation"
DOI: 10.1038/s41418-022-00955-8
Abstract: Acute promyelocytic leukemia (APL) is driven by the oncoprotein PML/RARα, which destroys the architecture of PML nuclear bodies (NBs). PML NBs are critical to tumor suppression, and their disruption mediated by PML/RARα accelerates APL pathogenesis.… read more here.
Keywords: phase separation; pml; apl; pml rar ... See more keywords
Long-term follow-up of children with acute promyelocytic leukemia treated with Beijing Children’s Hospital APL 2005 protocol (BCH-APL 2005)
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Hematology and Oncology"
DOI: 10.1080/08880018.2019.1621971
Abstract: Abstract We studied the outcomes of children with APL treated by the Beijing Children’s Hospital’s (BCH) acute promyelocytic leukemia (APL) 2005 protocol (BCH-APL2005). The clinical data of 77 patients enrolled from January 2005 to June… read more here.
Keywords: treated beijing; beijing children; children hospital; bch ... See more keywords
Comparing Azole Plasma Trough Levels in Lung Transplant Recipients: Percentage of Therapeutic Levels and Intrapatient Variability
Sign Up to like & getrecommendations! Published in 2017 at "Therapeutic Drug Monitoring"
DOI: 10.1097/ftd.0000000000000371
Abstract: Background: This study compared therapeutic azole plasma trough levels (APL) of the azole antimycotics itraconazole (ITR), voriconazole (VOR), and posaconazole (POS) in lung transplant recipients and analyzed the influencing factors. In addition, intrapatient variability for… read more here.
Keywords: pos liq; vor; pos; pos tab ... See more keywords
Successful Treatment With ATRA and Arsenic Trioxide for a Child With Down Syndrome and Acute Promyelocytic Leukemia.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pediatric Hematology/Oncology"
DOI: 10.1097/mph.0000000000001438
Abstract: Acute promyelocytic leukemia (APL) is rare in patients with Down syndrome (DS). Cytotoxic chemotherapy combined with all-trans retinoic acid (ATRA) has been a standard treatment for APL, but is potentially intolerable for DS patients because… read more here.
Keywords: acute promyelocytic; atra arsenic; apl; promyelocytic leukemia ... See more keywords
Acute promyelocytic leukaemia associated with atypical basophilia.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of haematology"
DOI: 10.1111/bjh.18793
Abstract: A 32yearold man presented with persistant asthenia, body aches and nausea one month after COVID19 infection. On examination, he had mild hepatomegaly, oedema of both legs and flat redpurple pruritic skin lesions exacerbated on the… read more here.
Keywords: leukaemia; apl; promyelocytic leukaemia; count ... See more keywords
p53 as a unique target of action of cisplatin in acute leukaemia cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17502
Abstract: Acute promyelocytic leukaemia (APL) occurs in approximately 10% of acute myeloid leukaemia patients. Arsenic trioxide (ATO) has been for APL chemotherapy, but recently several ATO‐resistant cases have been reported worldwide. Cisplatin (CDDP) enhances the toxicity… read more here.
Keywords: leukaemia; apl; action; leukaemia cells ... See more keywords
AB0552 Antiphospholipid antibodies in giant cell arteritis
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2017-eular.2508
Abstract: Objectives The aim of our prospective study was to evaluate the role of antiphospholipid antibodies (aPL) on the clinical presentation of giant cell arteritis (GCA). Methods GCA patients diagnosed for the first time between 1.… read more here.
Keywords: giant cell; double triple; cell arteritis; apl abs ... See more keywords
AB0479 The role of antibodies to xanthine oxidase and adenosine deaminase in the development of anti-phospholipid syndrome in patients with systemic lupus erythematosus
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2017-eular.4728
Abstract: Objectives The aim of the research was to study the processes of formation of antibodies to the enzyme purine metabolism (PM) - xanthine oxidase (XO) and adenosine deaminase (ADA) - in patients with systemic lupus… read more here.
Keywords: xanthine oxidase; class; anti; apl ... See more keywords
Recurrent RARB Translocations in Acute Promyelocytic Leukemia Lacking RARA Translocation.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-0840
Abstract: Translocations of retinoic acid receptor-α (RARA), typically PML-RARA, are a genetic hallmark of acute promyelocytic leukemia (APL). However, because a small fraction of APL lack translocations of RARA, we focused here on APL cases without… read more here.
Keywords: acute promyelocytic; rara; rarb; promyelocytic leukemia ... See more keywords
Belimumab in primary antiphospholipid syndrome
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DOI: 10.1177/0961203316682102
Abstract: Sir, Antiphospholipid syndrome (APS) is an autoimmune disease characterized by thrombosis and/ or pregnancy morbidity with persistently positive antiphospholipid antibodies (aPL). Patients with aPL may also experience thrombocytopenia, cardiac valve disease, nephropathy, skin ulcer, or… read more here.
Keywords: aps patients; antiphospholipid syndrome; disease; belimumab ... See more keywords