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   Articles with "apl progression" as a keyword



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TRIB3 Promotes APL Progression through Stabilization of the Oncoprotein PML-RARĪ± and Inhibition of p53-Mediated Senescence.

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recommendations! Published in 2017 at "Cancer cell"

DOI: 10.1016/j.ccell.2017.04.006

Abstract: Acute promyelocytic leukemia (APL) is driven by the oncoprotein PML-RARĪ±, which antagonizes myeloid differentiation and promotes APL-initiating cell self-renewal. Combined all-trans retinoic acid (ATRA) with arsenic trioxide (As2O3) or chemotherapy dramatically improves the prognosis of… read more here.

Keywords: rar; trib3; promotes apl; oncoprotein pml ... See more keywords