Recent advances in understanding clonal haematopoiesis in aplastic anaemia
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Haematology"
DOI: 10.1111/bjh.14510
Abstract: Acquired aplastic anaemia (AA) is an immune‐mediated bone marrow failure disorder inextricably linked to clonal haematopoiesis. The majority of AA patients have somatic mutations and/or structural chromosomal abnormalities detected as early as at diagnosis. In… read more here.
Keywords: clonal haematopoiesis; advances understanding; haematopoiesis; aplastic anaemia ... See more keywords
Distinctive and common features of moderate aplastic anaemia
Sign Up to like & getrecommendations! Published in 2020 at "British journal of haematology"
DOI: 10.1111/bjh.16460
Abstract: The therapy algorithm for severe aplastic anaemia (sAA) is established but moderate AA (mAA), which likely reflects a more diverse pathogenic mechanism, often represents a treatment/management conundrum. A cohort of AA patients (n = 325)… read more here.
Keywords: saa; aplastic anaemia; anaemia; common features ... See more keywords
Longitudinal evaluation of eltrombopag in paediatric acquired severe aplastic anaemia
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Haematology"
DOI: 10.1111/bjh.16766
Abstract: Aplastic anaemia in childhood is a rare, potentially life-threatening disease, characterised by peripheral blood pancytopenia, hypocellular bone marrow without dysplasia or fibrosis. It is usually acquired, caused by immune-mediated destruction of the haematopoietic progenitor cells.… read more here.
Keywords: ist; eltrombopag paediatric; acquired severe; aplastic anaemia ... See more keywords
Eltrombopag preferentially expands haematopoietic multipotent progenitors in human aplastic anaemia
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Haematology"
DOI: 10.1111/bjh.17140
Abstract: Eltrombopag has been added to first‐line treatment of immune aplastic anaemia (AA), resulting in higher responses. We analysed marrow samples of AA patients who responded to immunosuppressive therapy (IST) alone or in combination with eltrombopag… read more here.
Keywords: multipotent progenitors; preferentially expands; aplastic anaemia; eltrombopag preferentially ... See more keywords
Efficacy and safety of romiplostim in refractory aplastic anaemia: a Phase II/III, multicentre, open‐label study
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Haematology"
DOI: 10.1111/bjh.17190
Abstract: A previous dose‐finding study has suggested that romiplostim is effective in patients with refractory aplastic anaemia (AA) and 10 µg/kg once weekly was recommended as a starting dose. In this Phase II/III, multicentre, open‐label study,… read more here.
Keywords: refractory aplastic; study; aplastic anaemia; phase iii ... See more keywords
Clinical outcomes and immune responses to SARS‐CoV‐2 vaccination in severe aplastic anaemia
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Haematology"
DOI: 10.1111/bjh.18456
Abstract: Patients with severe aplastic anaemia (SAA) are often not vaccinated against viruses due to concerns of ineffective protective antibody response and potential for pathogenic global immune system activation, leading to relapse. We evaluated the impact… read more here.
Keywords: outcomes immune; clinical outcomes; severe aplastic; vaccination ... See more keywords
Haematopoietic stem cell transplantation for hepatitis-associated aplastic anaemia and non-hepatitis-associated aplastic anaemia: A propensity score-matched analysis.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of haematology"
DOI: 10.1111/bjh.18779
Abstract: To validate the efficacy and safety of haematopoietic stem cell transplantation (HSCT) in hepatitis‐associated aplastic anaemia (HAAA) patients, we reviewed 260 patients who underwent HSCT for acquired aplastic anaemia and eventually included 30 HAAA patients… read more here.
Keywords: haaa patients; anaemia; hepatitis associated; aplastic anaemia ... See more keywords
Revisiting acquired aplastic anaemia: current concepts in diagnosis and management
Sign Up to like & getrecommendations! Published in 2019 at "Internal Medicine Journal"
DOI: 10.1111/imj.14140
Abstract: Acquired aplastic anaemia is a rare, serious, immunologically mediated bone marrow failure syndrome, characterised by marrow hypoplasia of varying severity and significant pancytopenia. Careful attention and investigation, including molecular testing, is required to confirm the… read more here.
Keywords: revisiting acquired; diagnosis; acquired aplastic; management ... See more keywords
Cofilin‐1 participates in the hyperfunction of myeloid dendritic cells in patients with severe aplastic anaemia
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17359
Abstract: Cofilin‐1 interacts with actin to regulate cell movement. The importance of cofilin‐1 in immunity has been established, and its involvement in a number of autoimmune diseases has been confirmed. However, its role in severe aplastic… read more here.
Keywords: mdcs patients; severe aplastic; patients saa; myeloid dendritic ... See more keywords
Dose of deferasirox correlates with its effects, which differ between low‐risk myelodysplastic syndrome and aplastic anaemia
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Pharmacy and Therapeutics"
DOI: 10.1111/jcpt.13712
Abstract: Patients with low‐risk myelodysplastic syndrome (MDS) and aplastic anaemia (AA) often need transfusions, which may accelerate iron overload. The aim of this study was to evaluate the efficacy, safety and dose–effect relationships of deferasirox (DFX)… read more here.
Keywords: risk; risk myelodysplastic; low risk; myelodysplastic syndrome ... See more keywords
Long-term follow-up of hepatitis-associated aplastic anaemia
Sign Up to like & getrecommendations! Published in 2017 at "BMJ Case Reports"
DOI: 10.1136/bcr-2017-221434
Abstract: Prognosis of hepatitis-associated aplastic anaemia (HAAA) was improved with haematopoietic stem cell transplantation (HSCT) and immunosuppression, but the long-term outcome remains undefined. Case 1: a girl aged 3 years with acute liver failure (ALF) submitted… read more here.
Keywords: hepatitis associated; term; long term; associated aplastic ... See more keywords