Allogeneic hematopoietic stem cell transplantation for aplastic anemia with pre‐transplant conditioning using fludarabine, reduced‐dose cyclophosphamide, and low‐dose thymoglobulin: A KSGCT prospective study
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DOI: 10.1002/ajh.25693
Abstract: The optimal pre‐transplant conditioning for aplastic anemia (AA) remains unclear. We performed a prospective study on allogeneic transplantation from a related or unrelated donor for adult patients with AA. We assessed whether reduced‐dose cyclophosphamide (CY)… read more here.
Keywords: thymoglobulin; pre transplant; transplant conditioning; aplastic anemia ... See more keywords
Alemtuzumab in relapsed immune severe aplastic anemia: Long‐term results of a phase II study
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DOI: 10.1002/ajh.26924
Abstract: Immune severe aplastic anemia (SAA) is characterized by pancytopenia and immune‐mediated bone marrow destruction. SAA may be treated with hematopoietic stem cell transplantation (HSCT) or immunosuppressive therapy (IST). However, 30% of patients treated with IST… read more here.
Keywords: long term; term results; severe aplastic; immune severe ... See more keywords
Fatigue, symptom burden, and health‐related quality of life in patients with myelodysplastic syndrome, aplastic anemia, and paroxysmal nocturnal hemoglobinuria
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DOI: 10.1002/cam4.1953
Abstract: Fatigue is distressing and affects quality of life (QoL) among patients with myelodysplastic syndrome (MDS), aplastic anemia (AA), and paroxysmal nocturnal hemoglobinuria (PNH). Limited data exist on the impact of fatigue, QoL, and related symptoms… read more here.
Keywords: aplastic anemia; patients myelodysplastic; fatigue; anemia paroxysmal ... See more keywords
Extracellular vesicles from bone marrow mesenchymal stromal cells of severe aplastic anemia patients attenuate hematopoietic functions of CD34+ hematopoietic stem and progenitor cells
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DOI: 10.1002/cbin.11885
Abstract: Mesenchymal stromal cells (MSC) regulate hematopoiesis in the bone marrow (BM) niche and extracellular vesicles (EVs) released by BM‐MSC are important mediators of the cross‐talk between BM‐MSC and hematopoietic stem and progenitor cells (HSPC). We… read more here.
Keywords: extracellular vesicles; mesenchymal stromal; bone marrow; aplastic anemia ... See more keywords
Addition of eltrombopag to immunosuppressive therapy in patients with newly diagnosed aplastic anemia
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DOI: 10.1002/cncr.31658
Abstract: The immune‐mediated destruction of hematopoietic stem cells is implicated in the pathophysiology of aplastic anemia (AA). Immunosuppressive therapy (IST) using antithymocyte globulin and cyclosporine is successful in this setting. Eltrombopag is active in patients with… read more here.
Keywords: eltrombopag immunosuppressive; immunosuppressive therapy; addition eltrombopag; aplastic anemia ... See more keywords
Structural modeling of a novel TERC variant in a patient with aplastic anemia and short telomeres
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DOI: 10.1007/s00277-018-3415-5
Abstract: Dear Editor, Inherited bone marrow failure syndromes (IBMFS) are a heterogeneous group of genetic blood disorders in which there is usually some form of aplastic anemia, associatedwith a family history of the same disorder. In… read more here.
Keywords: aplastic anemia; anemia; terc variant; terc ... See more keywords
Aplastic anemia associated with Crohn’s disease: a tertiary center retrospective study
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DOI: 10.1007/s00277-019-03729-4
Abstract: Aplastic anemia (AA) has been reported to be associated with inflammatory bowel disease (IBD), but mostly with ulcerative colitis (UC). Little is known about the associations between AA and Crohn’s disease (CD). We aim to… read more here.
Keywords: aplastic anemia; anemia associated; disease; center ... See more keywords
A New Immunosuppressive Therapy for Very Severe Aplastic Anemia in Children with Autoantibodies
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DOI: 10.1007/s11596-022-2519-2
Abstract: At present, a number of very severe aplastic anemia (VSAA) patients cannot receive hematopoietic stem cell transplantation (HSCT) or standard immunosuppressive therapy (IST) due to the high cost of therapy, shortage of sibling donors, and… read more here.
Keywords: vsaa patients; csa hdp; therapy; immunosuppressive therapy ... See more keywords
Romiplostim is effective for eltrombopag-refractory aplastic anemia: results of a retrospective study
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DOI: 10.1007/s12185-020-02971-1
Abstract: Eltrombopag (EPAG) and romiplostim (ROM), thrombopoietin receptor-agonists with demonstrated efficacy against aplastic anemia (AA) in prospective controlled studies, were authorized in Japan for use in adults with aplastic anemia in 2017 and 2019, respectively. So… read more here.
Keywords: anemia; aplastic anemia; eltrombopag; ten patients ... See more keywords
Clinical impact of dysplastic changes in acquired aplastic anemia: A systematic study of bone marrow biopsies in children and adults.
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DOI: 10.1016/j.anndiagpath.2019.151459
Abstract: Aplastic anemia (AA) is a rare disorder characterized by suppression of bone marrow function, which can progress to myelodysplastic syndrome (MDS) or to acute myeloid leukemia (AML). To determine if there are characteristics in bone… read more here.
Keywords: aplastic anemia; marrow; marrow biopsies; mds ... See more keywords
Lessons from a patient with severe aplastic anemia complicated with COVID-19
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DOI: 10.1016/j.asjsur.2020.07.007
Abstract: Abstract COVID-19 patients with preexisting diseases are at high risk of worse clinical outcomes. There is little data about patients with different comorbidities and how to deal with them. We reported a case of a… read more here.
Keywords: anemia complicated; aplastic anemia; complicated covid; patient severe ... See more keywords