Chemical Evolution of Aplithianine Class of Serine/Threonine Kinase Inhibitors.
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DOI: 10.1021/acs.jmedchem.5c00649
Abstract: Chimeric kinase J-PKAcĪ± represents a potential therapeutic target for fibrolamellar hepatocellular carcinoma (FLHCC). Structure-based design and screening were applied to improve the potency of the marine-derived kinase inhibitor aplithianine A targeting J-PKAcĪ±. Three classes of… read more here.
Keywords: aplithianine class; evolution aplithianine; class; kinase ... See more keywords