Structures of apo Cas12a and its complex with crRNA and DNA reveal the dynamics of ternary complex formation and target DNA cleavage
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DOI: 10.1371/journal.pbio.3002023
Abstract: Cas12a is a programmable nuclease for adaptive immunity against invading nucleic acids in CRISPR–Cas systems. Here, we report the crystal structures of apo Cas12a from Lachnospiraceae bacterium MA2020 (Lb2) and the Lb2Cas12a+crRNA complex, as well… read more here.
Keywords: dna; crrna; apo cas12a; lb2cas12a crrna ... See more keywords