AHoJ: rapid, tailored search and retrieval of apo and holo protein structures for user-defined ligands
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1101/2022.09.05.496878
Abstract: Understanding the mechanism of action of a protein or designing better ligands for it often requires access to a bound (holo) and an unbound (apo) state of the protein. Resources for the quick and easy… read more here.
Keywords: apo holo; holo; defined ligands; user defined ... See more keywords
High-Affinity Single-Domain Antibodies for Analyzing Human Apo- and Holo-Transferrin
Sign Up to like & getrecommendations! Published in 2022 at "Acta Naturae"
DOI: 10.32607/actanaturae.11663
Abstract: A highly efficient technology for generating new monoclonal single-domain recombinant antibodies (nanobodies) was used to obtain a panel of nanobodies recognizing human apo- and/or holo-transferrin. This article is devoted to the primary analysis of the… read more here.
Keywords: apo holo; single domain; holo transferrin;
AlphaFold2-Based Characterization of Apo and Holo Protein Structures and Conformational Ensembles Using Randomized Alanine Sequence Scanning Adaptation: Capturing Shared Signature Dynamics and Ligand-Induced Conformational Changes
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms252312968
Abstract: Proteins often exist in multiple conformational states, influenced by the binding of ligands or substrates. The study of these states, particularly the apo (unbound) and holo (ligand-bound) forms, is crucial for understanding protein function, dynamics,… read more here.
Keywords: alanine sequence; holo; protein; randomized alanine ... See more keywords