Structure–function analysis of naturally occurring apolipoprotein A-I L144R, A164S and L178P mutants provides insight on their role on HDL levels and cardiovascular risk
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-020-03583-y
Abstract: Naturally occurring point mutations in apolipoprotein A-I (apoA-I), the major protein component of high-density lipoprotein (HDL), may affect plasma HDL-cholesterol levels and cardiovascular risk. Here, we evaluated the effect of human apoA-I mutations L144R (associated… read more here.
Keywords: a164s; cholesterol; hdl; apoa ... See more keywords
MO298A SPECIFIC TUBULAR APOA-I DISTRIBUTION IS ASSOCIATED TO FSGS RECURRENCE AFTER KIDNEY TRANSPLANTATION
Sign Up to like & getrecommendations! Published in 2021 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfab104.0056
Abstract: A major complication primary focal segmental glomerulosclerosis (FSGS) is its recurrence after kidney transplantation that happens in 30 to 40% of the patients. The diagnosis of this relapses is not always easy as the histological… read more here.
Keywords: kidney transplantation; fsgs recurrence; transplantation; kidney ... See more keywords
Therapeutic effect of human ApoA-I-Milano variant in aged transgenic mouse model of Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of pharmacology"
DOI: 10.1111/bph.16065
Abstract: BACKGROUND AND PURPOSE Therapies based on apolipoprotein A-I (ApoA-I), classically tested for cardiovascular diseases, were recently proposed for Alzheimer's disease (AD). Based on a drug reprofiling approach, our objective was to explore the use of… read more here.
Keywords: alzheimer disease; apoa milano; apoa; treatment ... See more keywords
CSL112 (Apolipoprotein A-I [Human]) Strongly Enhances Plasma Apoa-I and Cholesterol Efflux Capacity in Post-Acute Myocardial Infarction Patients: A PK/PD Substudy of the AEGIS-I Trial
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cardiovascular Pharmacology and Therapeutics"
DOI: 10.1177/10742484221121507
Abstract: Introduction: Cholesterol efflux capacity (CEC) is impaired following acute myocardial infarction (AMI). CSL112 is an intravenous preparation of human plasma-derived apoA-I formulated with phosphatidylcholine (PC). CSL112 is intended to improve CEC and thereby prevent early… read more here.
Keywords: csl112; apoa; plasma; cholesterol efflux ... See more keywords
Abnormal levels of apolipoprotein A-I in chronic thromboembolic pulmonary hypertension
Sign Up to like & getrecommendations! Published in 2021 at "Pulmonary Circulation"
DOI: 10.1177/20458940211010371
Abstract: Recent studies have shown low high-density lipoprotein cholesterol (HDL-C) and dysregulated lipid metabolism in chronic thromboembolic pulmonary hypertension (CTEPH). Apolipoprotein A-I (ApoA-I) is the major protein component of HDL-C and mediates most of its functions.… read more here.
Keywords: chronic thromboembolic; pulmonary hypertension; hdl; apoa ... See more keywords
Gain and loss events in the evolution of the apolipoprotein family in vertebrata
Sign Up to like & getrecommendations! Published in 2019 at "BMC Evolutionary Biology"
DOI: 10.1186/s12862-019-1519-8
Abstract: BackgroundVarious apolipoproteins widely distributed among vertebrata play key roles in lipid metabolism and have a direct correlation with human diseases as diagnostic markers. However, the evolutionary progress of apolipoproteins in species remains unclear. Nine human… read more here.
Keywords: gain loss; apolipoprotein family; apoa; loss events ... See more keywords
Time-resolved fluorescence based direct two-site apoA-I immunoassays and their clinical application in patients with suspected obstructive coronary artery disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.912578
Abstract: Objective High-density lipoprotein (HDL) is a heterogeneous group of subpopulations differing in protein/lipid composition and in their anti-atherogenic function. There is a lack of assays that can target the functionality of HDL particles related to… read more here.
Keywords: two site; suspected obstructive; apoa; site apoa ... See more keywords
ApoA-I-Mediated Lipoprotein Remodeling Monitored with a Fluorescent Phospholipid
Sign Up to like & getrecommendations! Published in 2019 at "Biology"
DOI: 10.3390/biology8030053
Abstract: We describe simple, sensitive and robust methods to monitor lipoprotein remodeling and cholesterol and apolipoprotein exchange, using fluorescent Lissamine Rhodamine B head-group tagged phosphatidylethanolamine (*PE) as a lipoprotein reference marker. Fluorescent Bodipy cholesterol (*Chol) and… read more here.
Keywords: plasma lipoproteins; fluorescent; apoa; lipoprotein remodeling ... See more keywords
Apolipoprotein A-II, a Player in Multiple Processes and Diseases
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DOI: 10.3390/biomedicines10071578
Abstract: Apolipoprotein A-II (apoA-II) is the second most abundant apolipoprotein in high-density lipoprotein (HDL) particles, playing an important role in lipid metabolism. Human and murine apoA-II proteins have dissimilar properties, partially because human apoA-II is dimeric… read more here.
Keywords: apolipoprotein player; role; multiple processes; apoa ... See more keywords
CIGB-258 Exerts Potent Anti-Inflammatory Activity against Carboxymethyllysine-Induced Acute Inflammation in Hyperlipidemic Zebrafish via the Protection of Apolipoprotein A-I
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24087044
Abstract: Inflammation and atherosclerosis are intimately associated via the production of dysfunctional high-density lipoproteins (HDL) and modification of apolipoprotein (apo) A-I. A putative interaction between CIGB-258 and apoA-I was investigated to provide mechanistic insight into the… read more here.
Keywords: cigb 258; apoa; cml; anti inflammatory ... See more keywords
Structural and Functional Changes of Reconstituted High-Density Lipoprotein (HDL) by Incorporation of α-synuclein: A Potent Antioxidant and Anti-Glycation Activity of α-synuclein and apoA-I in HDL at High Molar Ratio of α-synuclein
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26247485
Abstract: α-synuclein (α-syn) is a major culprit of Parkinson’s disease (PD), although lipoprotein metabolism is very important in the pathogenesis of PD. α-syn was expressed and purified using the pET30a expression vector from an E. coli… read more here.
Keywords: syn; glycation; molar ratio; rhdl ... See more keywords