Actions of Apolipoprotein A-IV on Insulin-Independent Glucose Control and Activation of Akt in Mouse Liver
Sign Up to like & getrecommendations! Published in 2018 at "Diabetes"
DOI: 10.2337/db18-1777-p
Abstract: Insulin resistance is a risk factor for type 2 diabetes, fatty liver and metabolic syndrome. We reported previously that apolipoprotein A-IV (ApoA4) increased insulin secretion, insulin sensitivity and improved glucose uptake in adipocytes by PI3K-Akt… read more here.
Keywords: insulin; insulin independent; apoa4; liver ... See more keywords
Single-cell RNA sequencing reveals a novel inhibitory effect of ApoA4 on NAFL mediated by liver-specific subsets of myeloid cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1038401
Abstract: The liver immune microenvironment is a key element in the development of hepatic inflammation in NAFLD. ApoA4 deficiency increases the hepatic lipid burden, insulin resistance, and metabolic inflammation. However, the effect of ApoA4 on liver… read more here.
Keywords: cell; apoa4; liver immune; apoa4 deficiency ... See more keywords
Increased BAT Thermogenesis in Male Mouse Apolipoprotein A4 Transgenic Mice
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24044231
Abstract: Dietary lipids induce apolipoprotein A4 (APOA4) production and brown adipose tissue (BAT) thermogenesis. Administration of exogenous APOA4 elevates BAT thermogenesis in chow-fed mice, but not high-fat diet (HFD)-fed mice. Chronic feeding of HFD attenuates plasma… read more here.
Keywords: bat thermogenesis; hfd; apoa4; bat ... See more keywords