Functional recombinant apolipoprotein A5 that is stable at high concentrations at physiological pH[S]
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Lipid Research"
DOI: 10.1194/jlr.d119000103
Abstract: APOA5 is a low-abundance exchangeable apolipoprotein that plays critical roles in human triglyceride (TG) metabolism. Indeed, aberrations in the plasma concentration or structure of APOA5 are linked to hypertriglyceridemia, hyperchylomicronemia, myocardial infarction risk, obesity, and… read more here.
Keywords: apolipoprotein; functional recombinant; apoa5; recombinant apolipoprotein ... See more keywords
Alterations in sorting and secretion of hepatic apoA5 induce hypertriglyceridemia due to short-term use of olanzapine
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.935362
Abstract: Long-term use of olanzapine, an antipsychotic drug, induces hypertriglyceridemia, resulting in a higher risk of cardiovascular disease. However, the effects and underlying mechanisms of short-term use of olanzapine on circulating triglyceride levels remain poorly understood.… read more here.
Keywords: use olanzapine; apoa5; term use; hepatic apoa5 ... See more keywords
Apolipoprotein A5 regulates intracellular triglyceride metabolism in adipocytes
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2017.7461
Abstract: It has previously been demonstrated that apolipoprotein A5 (apoA5) can be internalized by human adipocytes and significantly decreases intracellular triglyceride content. In the present study, endocytosis of apoA5 by adipocytes under different conditions, and the… read more here.
Keywords: metabolism adipocytes; triglyceride metabolism; present study; intracellular triglyceride ... See more keywords