A systematic review of LDLR, PCSK9, and APOB variants in Asia.
Sign Up to like & getrecommendations! Published in 2020 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2020.05.004
Abstract: BACKGROUND AND AIMS Genetic identification is a public health care concern for management of familial hypercholesterolemia (FH) associated cardiovascular morbidity and mortality. This study presents the spectrum and distribution of LDLR, APOB, PCSK9 gene mutations… read more here.
Keywords: apob; systematic review; review ldlr; pcsk9 ... See more keywords
The first Japanese cases of familial hypercholesterolemia due to a known pathogenic APOB gene variant, c.10580 G>A: p.(Arg3527Gln).
Sign Up to like & getrecommendations! Published in 2020 at "Journal of clinical lipidology"
DOI: 10.1016/j.jacl.2020.05.007
Abstract: BACKGROUND We previously showed that patients without pathogenic variants in the LDLR and PCSK9 genes comprised approximately 40% of familial hypercholesterolemia (FH) cases. OBJECTIVE Our aim was to identify novel causative variants in Japanese patients… read more here.
Keywords: apob; pathogenic variants; apob gene; japanese cases ... See more keywords
Increased serum concentration of apolipoprotein B is associated with an increased risk of reaching renal replacement therapy in patients with diabetic kidney disease
Sign Up to like & getrecommendations! Published in 2020 at "Renal Failure"
DOI: 10.1080/0886022x.2020.1745235
Abstract: Abstract Objective Few studies have investigated the association of apolipoprotein B (ApoB) with the progression of diabetic kidney disease (DKD) and the risk of renal replacement therapy (RRT). Method In this retrospective cohort study, a… read more here.
Keywords: risk; apob; diabetic kidney; rrt ... See more keywords
Enzyme-Linked Immunoassay-Based Quantitative Measurement of Apolipoprotein B (ApoB) in Dried Blood Spots, a Biomarker of Cardiovascular Disease Risk
Sign Up to like & getrecommendations! Published in 2017 at "Biodemography and Social Biology"
DOI: 10.1080/19485565.2017.1283582
Abstract: ABSTRACT Apolipoprotein B (ApoB) is a strong predictor of cardiovascular disease, which remains the leading cause of mortality in both higher and lower income countries. Here, we adapted an enzyme-linked immunosorbent assay (ELISA) development kit… read more here.
Keywords: apob; blood spots; dried blood; apolipoprotein apob ... See more keywords
A Translational Tool to Facilitate Use of Apolipoprotein B for Clinical Decision-Making.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical chemistry"
DOI: 10.1093/clinchem/hvac161
Abstract: BACKGROUND Despite recent large-scale discordance studies showing definitively that atherosclerotic cardiovascular disease (ASCVD) risk correlates better with apolipoprotein B (apoB) than with low-density lipoprotein cholesterol (LDL-C), the latter remains the recommended metric for guiding lipid-lowering… read more here.
Keywords: translational tool; apob; facilitate use; ascvd risk ... See more keywords
Interplay of Atherogenic Particle Number and Particle Size and the Risk of Coronary Heart Disease.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical chemistry"
DOI: 10.1093/clinchem/hvac172
Abstract: BACKGROUND We examined the interplay of apolipoprotein B (apoB) and LDL particle size, approximated by the LDL-cholesterol (LDL-C)/apoB ratio, on the risk of new-onset coronary heart disease (CHD). METHODS Participants without cardiovascular disease from the… read more here.
Keywords: disease; apob; risk; heart ... See more keywords
Reducing the Damage of Ox-LDL/LOX-1 Pathway to Vascular Endothelial Barrier Can Inhibit Atherosclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/7541411
Abstract: Aim The destruction of the vascular endothelial barrier mediated by Ox-LDL is the initial link to atherosclerosis. Here, we aimed to determine whether the immunological intervention with Ox-ApoB polypeptide fragment (Ox-ApoB-PF) can block the deposition… read more here.
Keywords: endothelial barrier; endothelial cells; apob; atherosclerosis ... See more keywords
Elevated apolipoprotein B predicts poor postsurgery prognosis in patients with hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "OncoTargets and therapy"
DOI: 10.2147/ott.s192631
Abstract: Aims To date, curative resection remains to be the most optimal therapeutic choice of hepatocellular carcinoma (HCC), though the overall survival (OS) remains extremely unsatisfactory. To better manage the HCC patients, we evaluated the prognosis… read more here.
Keywords: hepatocellular carcinoma; hcc; prognosis; apob ... See more keywords
Low Expression of APOB mRNA or Its Hypermethylation Predicts Favorable Overall Survival in Patients with Low-Grade Glioma
Sign Up to like & getrecommendations! Published in 2020 at "OncoTargets and therapy"
DOI: 10.2147/ott.s257794
Abstract: Background This study was performed to explore the clinical and prognostic significance of APOB mRNA expression, DNA methylation and APOB mutation in patients with low-grade glioma (LGG). Methods Bioinformatic analysis was conducted using genomic, clinical… read more here.
Keywords: expression; patients low; apob mrna; apob ... See more keywords
Single-cell transcriptomes and T cell receptors of vaccine-expanded apolipoprotein B-specific T cells
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.1076808
Abstract: Atherosclerotic cardiovascular diseases are the major cause of death worldwide. CD4 T cells responding to Apolipoprotein B (ApoB), the core protein of most lipoproteins, have been identified as critical disease modulators. In healthy individuals, ApoB-reactive… read more here.
Keywords: cell; apob; single cell; cell transcriptomes ... See more keywords
Identification and Functional Analysis of APOB Variants in a Cohort of Hypercholesterolemic Patients
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24087635
Abstract: Mutations in APOB are the second most frequent cause of familial hypercholesterolemia (FH). APOB is highly polymorphic, and many variants are benign or of uncertain significance, so functional analysis is necessary to ascertain their pathogenicity.… read more here.
Keywords: identification functional; analysis apob; apob; apob variants ... See more keywords