APOBEC3A Catalytic Inactivity Mutation Induces Tertiary Structure Destabilization.
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DOI: 10.1021/acsmedchemlett.2c00517
Abstract: APOBEC3A (A3A)-catalyzed DNA cytosine deamination is implicated in virus and cancer mutagenesis, and A3A is a target for small molecule drug discovery. The catalytic glutamic acid (E72) is frequently mutated in biochemical studies to characterize… read more here.
Keywords: a3a; apobec3a catalytic; inactivity mutation; mutation ... See more keywords