Divergence in dimerization and activity of primate APOBEC3C.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2021.167306
Abstract: The APOBEC3 (A3) family of single-stranded DNA cytidine deaminases are host restriction factors that inhibit lentiviruses, such as HIV-1, in the absence of the Vif protein that causes their degradation. Deamination of cytidine in HIV-1… read more here.
Keywords: amino; dimerization; a3c; apobec3c ... See more keywords
Induction of APOBEC3C facilitates the genotoxic stress-mediated cytotoxicity of artesunate.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.9b00358
Abstract: Artemisinin class of anticancer compounds is well-known for oxidative DNA damage-mediated growth arrest followed by cell death. However, the nature of this genotoxic stress for cancer therapeutics remains elusive. Here, we show that artesunate (Art),… read more here.
Keywords: dna damage; a3c; apobec3c; art ... See more keywords