Key differences between apoC-III regulation and expression in intestine and liver.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.07.116
Abstract: ApoC-III is a critical cardiovascular risk factor, and humans expressing null mutations in apoC-III are robustly protected from cardiovascular disease. Because of its critical role in elevating plasma lipids and CVD risk, hepatic apoC-III regulation… read more here.
Keywords: intestine; apoc; intestinal apoc; expression ... See more keywords
Inverse association between apolipoprotein C-II and cardiovascular mortality: role of lipoprotein lipase activity modulation.
Sign Up to like & getrecommendations! Published in 2023 at "European heart journal"
DOI: 10.1093/eurheartj/ehad261
Abstract: AIMS Apolipoprotein C-II (ApoC-II) is thought to activate lipoprotein lipase (LPL) and is therefore a possible target for treating hypertriglyceridemia. Its relationship with cardiovascular risk has not been investigated in large-scale epidemiologic studies, particularly allowing… read more here.
Keywords: lipoprotein lipase; cardiovascular mortality; activity; apoc ... See more keywords
A dual apolipoprotein C-II mimetic–apolipoprotein C-III antagonist peptide lowers plasma triglycerides
Sign Up to like & getrecommendations! Published in 2020 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aaw7905
Abstract: An apolipoprotein C-II peptide mimetic for the treatment of hypertriglyceridemia activates lipoprotein lipase and blocks apolipoprotein C-III. How low can you go? People with elevated plasma triglycerides face increased risk of cardiovascular disease. Wolska et… read more here.
Keywords: d6pv; apoc; plasma triglycerides; apolipoprotein iii ... See more keywords
ApoC-III ASO promotes tissue LPL activity in the absence of apoE-mediated TRL clearance[S]
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Lipid Research"
DOI: 10.1194/jlr.m093740
Abstract: Hypertriglyceridemia results from accumulation of triglyceride (TG)-rich lipoproteins (TRLs) in the circulation and is associated with increased CVD risk. ApoC-III is an apolipoprotein on TRLs and a prominent negative regulator of TG catabolism. We recently… read more here.
Keywords: apoe; apoc; apoc iii; trl clearance ... See more keywords