Key differences between apoC-III regulation and expression in intestine and liver.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.07.116
Abstract: ApoC-III is a critical cardiovascular risk factor, and humans expressing null mutations in apoC-III are robustly protected from cardiovascular disease. Because of its critical role in elevating plasma lipids and CVD risk, hepatic apoC-III regulation… read more here.
Keywords: intestine; apoc; intestinal apoc; expression ... See more keywords
Impact of bariatric surgery on apolipoprotein C-III levels and lipoprotein distribution in obese human subjects.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of clinical lipidology"
DOI: 10.1016/j.jacl.2017.02.012
Abstract: BACKGROUND Elevated apolipoprotein C-III (apoC-III) has been postulated to contribute to the atherogenic dyslipidemia seen in obesity and insulin-resistant states, mainly by impairing plasma triglyceride-rich lipoprotein (TRL) metabolism. Bariatric surgery is associated with improvements of… read more here.
Keywords: iii; surgery; bariatric surgery; hdl ... See more keywords
A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels
Sign Up to like & getrecommendations! Published in 2017 at "Nature Medicine"
DOI: 10.1038/nm.4390
Abstract: Recent large-scale genetic sequencing efforts have identified rare coding variants in genes in the triglyceride-rich lipoprotein (TRL) clearance pathway that are protective against coronary heart disease (CHD), independently of LDL cholesterol (LDL-C) levels. Insight into… read more here.
Keywords: human apoc3; iii; clearance; apoc iii ... See more keywords
N-acetyl galactosamine-conjugated antisense drug to APOC3 mRNA, triglycerides and atherogenic lipoprotein levels
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz209
Abstract: Abstract Aims Elevated apolipoprotein C-III (apoC-III) levels are associated with hypertriglyceridaemia and coronary heart disease. AKCEA-APOCIII-LRx is an N-acetyl galactosamine-conjugated antisense oligonucleotide targeted to the liver that selectively inhibits apoC-III protein synthesis. Methods and results… read more here.
Keywords: akcea apociii; galactosamine conjugated; acetyl galactosamine; apociii lrx ... See more keywords
Tocilizumab-related hypertriglyceridemia is independent of key molecules regulating lipid metabolism.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of clinical investigation"
DOI: 10.1111/eci.14006
Abstract: INTRODUCTION Tocilizumab(TCZ) treatment is associated with dyslipidemia, including a rise in triglycerides through a mechanism poorly understood. Three molecules play key roles in the regulation of triglyceride metabolism: apolipoprotein C-III(ApoC-III), angiopoietin-like protein 4(ANGPLT4), and lipoprotein… read more here.
Keywords: metabolism; tocilizumab; tcz treatment; regulatory molecules ... See more keywords
Association of apolipoprotein Cs with new-onset type 2 diabetes mellitus: findings from the Chinese multi-provincial cohort study
Sign Up to like & getrecommendations! Published in 2021 at "BMJ Open"
DOI: 10.1136/bmjopen-2021-052388
Abstract: Objectives Apolipoprotein Cs (apoCs), especially apoC-II and apoC-III, as the components of triglyceride-rich lipoproteins, play a key role in the pathophysiology of diabetes. However, prospective studies examining direct associations between apoCs and diabetes are not… read more here.
Keywords: study; association; new onset; cohort study ... See more keywords
Correlation between Serum ApoC III and Galectin-3 Levels and Maternal and Neonatal Adverse Outcomes in Gestational Diabetes Mellitus Patients
Sign Up to like & getrecommendations! Published in 2022 at "Emergency Medicine International"
DOI: 10.1155/2022/5089529
Abstract: Objective The correlation between serum ApoC III and galectin-3 levels and adverse maternal and infant outcomes in GDM patients was analyzed. Methods A total of 97 GDM patients admitted to our hospital from January 2019… read more here.
Keywords: iii galectin; apoc iii; galectin; pregnancy outcomes ... See more keywords
Complex association of apolipoprotein E–containing HDL with coronary artery disease burden in cardiovascular disease
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.159577
Abstract: Background Although traditional lipid parameters and coronary imaging techniques are valuable for cardiovascular disease (CVD) risk prediction, better diagnostic tests are still needed. Methods In a prospective, observational study, 795 individuals had extensive cardiometabolic profiling,… read more here.
Keywords: disease; containing hdl; apoc iii; coronary artery ... See more keywords
Postprandial metabolism of apolipoproteins B48, B100, C-III, and E in humans with APOC3 loss-of-function mutations
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.160607
Abstract: Background Apolipoprotein C-III (apoC-III) is a regulator of triglyceride (TG) metabolism, and due to its association with risk of cardiovascular disease, is an emergent target for pharmacological intervention. The impact of substantially lowering apoC-III on… read more here.
Keywords: b48 b100; metabolism; apolipoproteins b48; iii ... See more keywords
ApoC-III ASO promotes tissue LPL activity in the absence of apoE-mediated TRL clearance[S]
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Lipid Research"
DOI: 10.1194/jlr.m093740
Abstract: Hypertriglyceridemia results from accumulation of triglyceride (TG)-rich lipoproteins (TRLs) in the circulation and is associated with increased CVD risk. ApoC-III is an apolipoprotein on TRLs and a prominent negative regulator of TG catabolism. We recently… read more here.
Keywords: apoe; apoc; apoc iii; trl clearance ... See more keywords
Distinct patterns of apolipoprotein C-I, C-II and C-III isoforms are associated with markers of Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of lipid research"
DOI: 10.1194/jlr.ra120000919
Abstract: Apolipoproteins C-I, C-II and C-III interact with ApoE to regulate lipoprotein metabolism and contribute to Alzheimer's disease pathophysiology. In plasma, apoC-I and C-II exist as truncated isoforms, while apoC-III exhibits multiple glycoforms. This study aimed… read more here.
Keywords: distinct patterns; csf; alzheimer disease; iii isoforms ... See more keywords