Definitive roles of TOMM40-APOE-APOC1 variants in the Alzheimer's risk
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of aging"
DOI: 10.1016/j.neurobiolaging.2021.09.009
Abstract: Despite advances, the roles of genetic variants from the APOE-harboring 19q13.32 region in Alzheimer's disease (AD) remain controversial. We leverage a comprehensive approach to gain insights into a more homogeneous genetic architecture of AD in… read more here.
Keywords: apoc1 variants; apoe apoc1; definitive roles; tomm40 apoe ... See more keywords
ApoC1 promotes glioma metastasis by enhancing epithelial-mesenchymal transition and activating the STAT3 pathway
Sign Up to like & getrecommendations! Published in 2022 at "Neurological Research"
DOI: 10.1080/01616412.2022.2132458
Abstract: ABSTRACT Objective: One of the apolipoprotein’s members, apolipoprotein C1 (ApoC1), is critical in the metabolism of both very-low-density lipoprotein (VLDL) and high-density lipoprotein (HDL) cholesterols. Multiple studies have recently revealed that ApoC1 may be a… read more here.
Keywords: mesenchymal transition; apoc1; glioma; epithelial mesenchymal ... See more keywords
APOE ɛ4 allele and TOMM40‐APOC1 variants jointly contribute to survival to older ages
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13730
Abstract: Age‐related diseases characteristic of post‐reproductive life, aging, and life span are the examples of polygenic non‐Mendelian traits with intricate genetic architectures. Polygenicity of these traits implies that multiple variants can impact their risks independently or… read more here.
Keywords: survival older; tomm40; carriers minor; older ages ... See more keywords
Biothiols and oxidative stress markers and polymorphisms of TOMM40 and APOC1 genes in Alzheimer’s disease patients
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.26184
Abstract: Alzheimer’s disease (AD) is a progressive disease, with frequently observed improper biothiols turnover, homocysteine (Hcy) and glutathione (GSH). GSH protects cells from oxidative stress and may be determined by 8-oxo-2’-deoxyguanosine (8-oxo2dG) level and its repair… read more here.
Keywords: rs2075650; disease; gsh; apoc1 ... See more keywords
APOC1 as a novel diagnostic biomarker for DN based on machine learning algorithms and experiment
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1102634
Abstract: Introduction Diabetic nephropathy is the leading cause of end-stage renal disease, which imposes a huge economic burden on individuals and society, but effective and reliable diagnostic markers are still not available. Methods Differentially expressed genes… read more here.
Keywords: novel diagnostic; apoc1 novel; expression; diagnostic biomarker ... See more keywords
Apolipoprotein C1 (APOC1): A Novel Diagnostic and Prognostic Biomarker for Clear Cell Renal Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.01436
Abstract: Background: Apolipoprotein C1 (APOC1) has been proved to play a critical role in gastric, breast, lung, and pancreatic cancer. However, the relationship between APOC1 and urinary tumors remains unclear. This study aimed to assess the… read more here.
Keywords: diagnostic prognostic; novel diagnostic; apolipoprotein apoc1; expression ... See more keywords
The Mean ApoC1 Serum Level in Postoperative Samples from Neurosurgical Patients Is Lower than in Preoperative Samples and during Chemotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11071021
Abstract: Simple Summary Apolipoprotein C1 is mainly synthesized in the liver and helps in the digestion of fatty acids and in their clearance from the bloodstream. Recent reports have described the role of ApoC1 in malignant… read more here.
Keywords: serum; level; apoc1; mean apoc1 ... See more keywords