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   Articles with "apoe" as a keyword



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Decreased content, rate of synthesis and export of cholesterol in the brain of apoE knockout mice

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recommendations! Published in 2018 at "Journal of Bioenergetics and Biomembranes"

DOI: 10.1007/s10863-018-9757-9

Abstract: Apolipoprotein E knockout (apoE-KO) mice present synaptic loss, cognitive dysfunction, and high plasma lipid levels that may affect brain function simulating Alzheimer disease. Plasma and brain sterols were measured in apoE-KO and in wild type… read more here.

Keywords: apoe; cholesterol; mice; brain ... See more keywords
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Early-life educational attainment, APOE ε4 alleles, and incident dementia risk in late life.

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recommendations! Published in 2022 at "GeroScience"

DOI: 10.1007/s11357-022-00545-z

Abstract: We examined the interactions between educational attainment and genetic susceptibility on dementia risk among adults over 60 years old. A total of 174,161 participants were free of dementia at baseline. The APOE ε4-related genetic risk was… read more here.

Keywords: risk; dementia risk; apoe; educational attainment ... See more keywords
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Responses to executive demand in young adulthood differ by APOE genotype

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recommendations! Published in 2019 at "Behavioural Brain Research"

DOI: 10.1016/j.bbr.2018.11.033

Abstract: ABSTRACT Despite evidence of a relationship between Apolipoprotein E (APOE) &egr;4+ and later‐life cognitive decline, the lifespan effects of carrying an &egr;4+ allele on cognitive ageing are not well understood. Evidence of &egr;4+ advantages in… read more here.

Keywords: executive demand; apoe; egr; verbal fluency ... See more keywords
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Characterizing the human APOE epsilon 4 knock-in transgene in female and male rats with multimodal magnetic resonance imaging

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recommendations! Published in 2020 at "Brain Research"

DOI: 10.1016/j.brainres.2020.147030

Abstract: The APOE Ɛ4 genotype is the most prevalent genetic risk for Alzheimer's disease (AD). Women carriers of Ɛ4 have higher risk for an early onset of AD than men. Human imaging studies suggest apolipoprotein Ɛ4… read more here.

Keywords: knock; apoe; diffusion; connectivity ... See more keywords
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Therapeutic potential of ApoE-mimetic peptides in CNS disorders: Current perspective

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recommendations! Published in 2022 at "Experimental Neurology"

DOI: 10.1016/j.expneurol.2022.114051

Abstract: The prevalence and burden of CNS disorders are increasing significantly due to the increase in life span and population. The contemporary need in CNS drug discovery is to develop the therapy that can halt the… read more here.

Keywords: therapeutic potential; apoe mimetic; cns disorders; apoe ... See more keywords
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Plasma apolipoproteins and physical and cognitive health in very old individuals

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recommendations! Published in 2017 at "Neurobiology of Aging"

DOI: 10.1016/j.neurobiolaging.2017.02.017

Abstract: Apolipoproteins play a crucial role in lipid metabolism with implications in cardiovascular disease, obesity, diabetes, Alzheimer's disease, and longevity. We quantified 7 apolipoproteins in plasma in 1067 individuals aged 56-105 using immunoassays and explored relationships… read more here.

Keywords: apoe; cognitive health; apolipoproteins physical; health ... See more keywords
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The effect of APOE genotype on Alzheimer's disease risk is influenced by sex and docosahexaenoic acid status

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recommendations! Published in 2018 at "Neurobiology of Aging"

DOI: 10.1016/j.neurobiolaging.2018.05.017

Abstract: An apolipoprotein E ε4 (APOE-ε4) genotype is the strongest common genetic determinant of Alzheimer's disease (AD). The pleiotropic nature of apolipoprotein E has made elucidation of the aetiological basis difficult to establish, which is further… read more here.

Keywords: apoe genotype; risk; docosahexaenoic acid; apoe ... See more keywords
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APOE effects on cognition from childhood to adolescence

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recommendations! Published in 2019 at "Neurobiology of Aging"

DOI: 10.1016/j.neurobiolaging.2019.04.011

Abstract: The ε4 allele of APOE is a well-established genetic risk factor for cognitive aging and dementia, but its influence on early life cognition is unknown. Consequently, we assessed associations of APOE genotypes with cognitive performance… read more here.

Keywords: full scale; childhood adolescence; apoe; cognition ... See more keywords
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KL∗VS heterozygosity reduces brain amyloid in asymptomatic at-risk APOE∗4 carriers

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recommendations! Published in 2021 at "Neurobiology of Aging"

DOI: 10.1016/j.neurobiolaging.2021.01.008

Abstract: KLOTHO∗VS heterozygosity (KL∗VSHET+) was recently shown to be associated with reduced risk of Alzheimer's disease (AD) in APOE∗4 carriers. Additional studies suggest that KL∗VSHET+ protects against amyloid burden in cognitively normal older subjects, but sample… read more here.

Keywords: risk; apoe; heterozygosity reduces; apoe carriers ... See more keywords
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Intérêt de la stratification par âge dans l’estimation du risque lié au génotype APOE dans la maladie d’Alzheimer

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recommendations! Published in 2019 at "Revue Neurologique"

DOI: 10.1016/j.neurol.2019.01.047

Abstract: Introduction Les interactions entre l’âge, le sexe et le genotype de l’apolipoproteine E (APOE), les trois principaux facteurs de risque de la maladie d’Alzheimer (MA), ne sont que partiellement elucidees. Objectifs Determiner l’effet du genotype… read more here.

Keywords: genotype; maladie alzheimer; chez les; apoe ... See more keywords
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Overexpressing low-density lipoprotein receptor reduces tau-associated neurodegeneration in relation to apoE-linked mechanisms

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recommendations! Published in 2021 at "Neuron"

DOI: 10.1016/j.neuron.2021.05.034

Abstract: APOE is the strongest genetic risk factor for late-onset Alzheimer's disease. ApoE exacerbates tau-associated neurodegeneration by driving microglial activation. However, how apoE regulates microglial activation and whether targeting apoE is therapeutically beneficial in tauopathy is… read more here.

Keywords: apoe; neurodegeneration; tau associated; activation ... See more keywords