KL∗VS heterozygosity reduces brain amyloid in asymptomatic at-risk APOE∗4 carriers
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2021.01.008
Abstract: KLOTHO∗VS heterozygosity (KL∗VSHET+) was recently shown to be associated with reduced risk of Alzheimer's disease (AD) in APOE∗4 carriers. Additional studies suggest that KL∗VSHET+ protects against amyloid burden in cognitively normal older subjects, but sample… read more here.
Keywords: risk; apoe; heterozygosity reduces; apoe carriers ... See more keywords
Brain Homotopic Connectivity in Mild Cognitive Impairment APOE-ε4 Carriers
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2020.04.011
Abstract: Individuals with mild cognitive impairment (MCI) are regarded as being at high risk of developing Alzheimer's disease (AD). The apolipoprotein E (APOE) ε4 allele is a well-established genetic risk factor for developing AD. In the… read more here.
Keywords: seed; connectivity; apoe carriers; mci apoe ... See more keywords
Connectome Signatures of Hyperexcitation in Cognitively Intact Middle-Aged Female APOE-ε4 Carriers.
Sign Up to like & getrecommendations! Published in 2020 at "Cerebral cortex"
DOI: 10.1093/cercor/bhaa190
Abstract: Synaptic dysfunction is hypothesized to be one of the earliest brain changes in Alzheimer's disease, leading to "hyperexcitability" in neuronal circuits. In this study, we evaluated a novel hyperexcitation indicator (HI) for each brain region… read more here.
Keywords: apoe; cognitively intact; intact middle; apoe carriers ... See more keywords
Resting‐state brain signal complexity discriminates young healthy APOE e4 carriers from non‐e4 carriers
Sign Up to like & getrecommendations! Published in 2023 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.15915
Abstract: It is well established that the e4 allele of the APOE gene is associated with impaired brain functionality and cognitive decline in humans at elder age. However, it is controversial whether and how the APOE… read more here.
Keywords: young healthy; brain; signal complexity; apoe ... See more keywords
Clinical phenotype, atrophy, and small vessel disease in APOEε2 carriers with Alzheimer disease
Sign Up to like & getrecommendations! Published in 2018 at "Neurology"
DOI: 10.1212/wnl.0000000000006503
Abstract: Objective To examine the clinical phenotype, gray matter atrophy patterns, and small vessel disease in patients who developed prodromal or probable Alzheimer disease dementia, despite carrying the protective APOEε2 allele. Methods We included 36 β-amyloid-positive… read more here.
Keywords: clinical phenotype; alzheimer disease; disease; apoe carriers ... See more keywords
Verbal memory improvement in first-episode psychosis APOE-ε4 carriers: a pleiotropic effect?
Sign Up to like & getrecommendations! Published in 2017 at "Neuropsychiatric Disease and Treatment"
DOI: 10.2147/ndt.s150488
Abstract: Background Verbal memory impairment is a core feature in schizophrenia even at early stages of the disease, but its etiopathogenesis is not fully understood. The APOE-ε4 is the main genetic risk factor for late-onset Alzheimer’s… read more here.
Keywords: pleiotropic effect; apoe carriers; memory; verbal memory ... See more keywords
Interactive Effects of Apolipoprotein E ε4 and Triiodothyronine on Memory Performance in Patients With Subjective Cognitive Decline
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2020.00298
Abstract: Background: The aim of the present study was to investigate the associations between thyroid hormones, cognitive performance, and apolipoprotein E (APOE) genotype in euthyroid patients with subjective cognitive decline (SCD). Methods: We recruited 197 euthyroid… read more here.
Keywords: apoe carriers; memory performance; performance; memory ... See more keywords