Functional segregation loss over time is moderated by APOE genotype in healthy elderly
Sign Up to like & getrecommendations! Published in 2018 at "Human Brain Mapping"
DOI: 10.1002/hbm.24036
Abstract: We investigated the influence of the apolipoprotein E‐ɛ4 allele (APOE‐ɛ4) on longitudinal age‐related changes in brain functional connectivity (FC) and cognition, in view of mixed cross‐sectional findings. One hundred and twenty‐two healthy older adults (aged… read more here.
Keywords: apoe genotype; functional segregation; moderated apoe; segregation ... See more keywords
APOE genotype modifies the association between central arterial stiffening and cognition in older adults
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2018.02.009
Abstract: Arterial stiffening is associated with cognitive impairment and prodromal Alzheimer's disease. This study tested the interaction between arterial stiffening and an Alzheimer's disease genetic risk factor (apolipoprotein E [APOE] genotype) on cognition among older adults. Vanderbilt… read more here.
Keywords: apoe genotype; central arterial; arterial stiffening; cognition ... See more keywords
The effect of APOE genotype on Alzheimer's disease risk is influenced by sex and docosahexaenoic acid status
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2018.05.017
Abstract: An apolipoprotein E ε4 (APOE-ε4) genotype is the strongest common genetic determinant of Alzheimer's disease (AD). The pleiotropic nature of apolipoprotein E has made elucidation of the aetiological basis difficult to establish, which is further… read more here.
Keywords: apoe genotype; risk; docosahexaenoic acid; apoe ... See more keywords
The relation between APOE genotype and cerebral microbleeds in cognitively unimpaired middle- and old-aged individuals
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2020.06.015
Abstract: Positive associations between cerebral microbleeds (CMBs) and APOE-ε4 (apolipoprotein E) genotype have been reported in Alzheimer's disease, but show conflicting results. We investigated the effect of APOE genotype on CMBs in a cohort of cognitively… read more here.
Keywords: apoe genotype; middle old; old aged; cognitively unimpaired ... See more keywords
Alzheimer’s Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways
Sign Up to like & getrecommendations! Published in 2020 at "Neuron"
DOI: 10.1016/j.neuron.2020.02.034
Abstract: Evidence suggests interplay among the three major risk factors for Alzheimer's disease (AD): age, APOE genotype, and sex. Here, we present comprehensive datasets and analyses of brain transcriptomes and blood metabolomes from human apoE2-, apoE3-,… read more here.
Keywords: apoe genotype; genotype sex; age; risk factors ... See more keywords
Association of oily fish intake, sex, age, BMI and APOE genotype with plasma long-chain n-3 fatty acid composition
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Nutrition"
DOI: 10.1017/s000711451800106x
Abstract: Abstract n-3 Fatty acids are associated with better cardiovascular and cognitive health. However, the concentration of EPA, DPA and DHA in different plasma lipid pools differs and factors influencing this heterogeneity are poorly understood. Our… read more here.
Keywords: apoe genotype; plasma; age; sex ... See more keywords
APOE Genotype Effects on Intrinsic Brain Network Connectivity in Patients with Amnestic Mild Cognitive Impairment
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-00432-0
Abstract: Whether and how the apolipoprotein E (APOE) ε4 genotype specifically modulates brain network connectivity in patients with amnestic mild cognitive impairment (aMCI) remain largely unknown. Here, we employed resting-state (‘task-free’) functional MRI and network centrality… read more here.
Keywords: apoe genotype; network; genotype; network connectivity ... See more keywords
APOE genotype influences insulin resistance, apolipoprotein CII and CIII according to plasma fatty acid profile in the Metabolic Syndrome
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-05802-2
Abstract: Metabolic markers associated with the Metabolic Syndrome (MetS) may be affected by interactions between the APOE genotype and plasma fatty acids (FA). In this study, we explored FA-gene interactions between the missense APOE polymorphisms and… read more here.
Keywords: apoe genotype; plasma; plasma fatty; metabolic syndrome ... See more keywords
Plasma levels of apolipoprotein E, APOE genotype, and all-cause and cause-specific mortality in 105 949 individuals from a white general population cohort
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz402
Abstract: Abstract Aims To determine whether plasma apoE levels and APOE genotype are associated with all-cause and cause-specific mortality. Methods and results Using a prospective cohort design with 105 949 white individuals from the general population,… read more here.
Keywords: apoe genotype; plasma apoe; cause; mortality ... See more keywords
APOE Genotype and Statin Response: Evidence From the UK Biobank and All of Us Program
Sign Up to like & getrecommendations! Published in 2025 at "Clinical and Translational Science"
DOI: 10.1111/cts.70314
Abstract: APOE genotype may affect statin response. Using UK Biobank (UKB) and All of Us (AoU) data, we aimed to investigate associations between APOE genotype, statin use, and key health outcomes. Our analysis included UKB baseline… read more here.
Keywords: statin response; apoe genotype; risk; mortality ... See more keywords
Sex and APOE genotype influence respiratory function under hypoxic and hypoxic-hypercapnic conditions
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Neurophysiology"
DOI: 10.1152/jn.00255.2023
Abstract: The apolipoprotein (APOE) gene has been studied due to its influence on Alzheimer's disease (AD) development and work in an APOE mouse model recently demonstrated impaired respiratory motor plasticity following spinal cord injury (SCI). Individuals… read more here.
Keywords: apoe genotype; influence; hypoxic; sex ... See more keywords