Effect of Apolipoprotein E isoforms on the Abundance and Function of P-glycoprotein in Human Brain Microvascular Endothelial Cells
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DOI: 10.1007/s11095-024-03731-0
Abstract: Individuals with Alzheimer’s disease (AD) often require many medications; however, these medications are dosed using regimens recommended for individuals without AD. This is despite reduced abundance and function of P-glycoprotein (P-gp) at the blood-brain barrier… read more here.
Keywords: abundance; isoforms abundance; function; apoe isoforms ... See more keywords
Association between APOE genotype and microglial cell morphology.
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DOI: 10.1093/jnen/nlad031
Abstract: APOE is the largest genetic risk factor for late-onset Alzheimer disease (AD) with E4 conferring an increased risk for AD compared to E3. The ApoE protein can impact diverse pathways in the brain including neuroinflammation… read more here.
Keywords: morphology; smtg; apoe isoforms; dementia ... See more keywords
Effect of ApoE isoforms on mitochondria in Alzheimer disease
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DOI: 10.1212/wnl.0000000000009582
Abstract: Objective To test the hypothesis that ApoE isoforms affect mitochondrial structure and function that are related to cognitive impairment in Alzheimer disease (AD), we systematically investigated the effects of ApoE isoforms on mitochondrial biogenesis and… read more here.
Keywords: apoe isoforms; apoe; alzheimer disease; oxidative stress ... See more keywords