Association between APOE genotype and microglial cell morphology.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlad031
Abstract: APOE is the largest genetic risk factor for late-onset Alzheimer disease (AD) with E4 conferring an increased risk for AD compared to E3. The ApoE protein can impact diverse pathways in the brain including neuroinflammation… read more here.
Keywords: morphology; smtg; apoe isoforms; dementia ... See more keywords
Effect of ApoE isoforms on mitochondria in Alzheimer disease
Sign Up to like & getrecommendations! Published in 2020 at "Neurology"
DOI: 10.1212/wnl.0000000000009582
Abstract: Objective To test the hypothesis that ApoE isoforms affect mitochondrial structure and function that are related to cognitive impairment in Alzheimer disease (AD), we systematically investigated the effects of ApoE isoforms on mitochondrial biogenesis and… read more here.
Keywords: apoe isoforms; apoe; alzheimer disease; oxidative stress ... See more keywords