Non-coding variability at the APOE locus contributes to the Alzheimer’s risk
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-10945-z
Abstract: Alzheimer’s disease (AD) is a leading cause of mortality in the elderly. While the coding change of APOE-ε4 is a key risk factor for late-onset AD and has been believed to be the only risk… read more here.
Keywords: apoe locus; non coding; risk; risk haplotypes ... See more keywords
Haplotype analysis of APOE intragenic SNPs
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DOI: 10.1186/s12868-018-0413-4
Abstract: BackgroundAPOE ε4 allele is most common genetic risk factor for Alzheimer’s disease (AD) and cognitive decline. However, it remains poorly understood why only some carriers of APOE ε4 develop AD and how ethnic variabilities in APOE locus… read more here.
Keywords: apoe; snps; haplotype; apoe locus ... See more keywords
Genetic Variants at the APOE Locus Predict Cardiometabolic Traits and Metabolic Syndrome: A Taiwan Biobank Study
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DOI: 10.3390/genes13081366
Abstract: Several apolipoprotein genes are located at the APOE locus on chromosome 19q13.32. This study explored the genetic determinants of cardiometabolic traits and metabolic syndrome at the APOE locus in a Taiwanese population. A total of… read more here.
Keywords: metabolic syndrome; traits metabolic; taiwan biobank; apoe locus ... See more keywords